
- 430 pages
- English
- PDF
- Available on iOS & Android
About this book
The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.
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Table of contents
- Endothelial Dysfunction - Old Concepts and New Challenges
- Contents
- Preface
- Chapter 1 Endothelium at a Glance
- Chapter 2 Hox Genes in Adult Tissues and Their Role in Endothelial Cell Differentiation and Angiogenesis
- Chapter 3 Endothelial Cell Senescence in the Pathogenesis of Endothelial Dysfunction
- Chapter 4 Targeting Endothelial SIRT1 for the Prevention of Arterial Aging
- Chapter 5 Sensing Fluid-Shear Stress in the Endothelial System with a Special Emphasis on the Primary Cilium
- Chapter 6 Endothelial Dysfunction as a Consequence of Endothelial Glycocalyx Damage: A Role in the Pathogenesis of Preeclampsia
- Chapter 7 Endothelial Cell von Willebrand Factor Secretion in Health and Cardiovascular Disease
- Chapter 8 Hyperglycemia-Induced Endothelial Dysfunction
- Chapter 9 Impact of Advanced Glycation End Products on Endothelial Function and Their Potential Link to Atherosclerosis
- Chapter 10 Endothelial Dysfunction in Type 2 Diabetes: Targeting Inflammation
- Chapter 11 Angiogenesis in Adipose Tissue: How can Moderate Caloric Restriction Affects Obesity-Related Endothelial Dysfunction?
- Chapter 12 Pulmonary Vascular Endothelial Cells
- Chapter 13 Smoking, Respiratory Diseases and Endothelial Dysfunction
- Chapter 14 Vascular Sympathetic Neurotransmission and Endothelial Dysfunction
- Chapter 15 Endothelial Cell Dysfunction in HIV-1 Infection
- Chapter 16 Selected Endothelial Responses after Ionizing Radiation Exposure
- Chapter 17 The Markers of Endothelial Activation