Remote C-H Bond Functionalizations

Methods and Strategies in Organic Synthesis

Debabrata Maiti, Srimanta Guin

• Publisher: Wiley-VCH
• Year: 2021
• Print ISBN:
  9783527346677
• eBook ISBN:
  9783527824144
• Edition: 1
• Topic: Physical Sciences
• Subtopic: Physical & Theoretical Chemistry

A guide to contemporary advancements in the field of distal C-H functionalizations 

An important and dynamic topic within the modern field of organic synthesis, selective functionalization of C-H bonds can be used in a variety of applications across the pharmaceutical and agrochemical industries. Remote C-H Bond Functionalizations presents an inclusive account of the most recent developments and potential applications of performing variegated functionalizations selectively at the distal positions of organic compounds.  

Featuring contributions by an international team of experts, this authoritative volume provides deep insight into distal functionalizations, including detailed discussion of mechanisms, the engineering of templates, and the design of strategies. The text covers a diverse range of topics including C-H functionalization of palladium/norbornene catalysis, ruthenium-catalyzed remote functionalization, the non-directed distal C(sp2)-H, functionalization, transition metal catalyzed distal para-selective C-H functionalization, and much more. Reviewing contemporary advancements in the field while laying the foundation for future research, this important resource: 

• Provides the most recent research and thorough coverage of the subject available in a single volume 
• Offers practical information on C-H functionalizations in various industries 
• Includes an up-to-date introduction to distal C-H functionalizations 

Remote C-H Bond Functionalizations is a must-read for every synthetic chemist, including chemists working with organometallics, organic chemists and researchers, and industrial chemists. 

Table of contents

• Cover
• Table of Contents
• Title Page
• Copyright
• 1 Introduction
• 2 Transition Metal‐Catalyzed Remote meta‐C–H Functionalization of Arenes Assisted by meta‐Directing Templates
• 3 C–H Functionalization of Arenes Under Palladium/Norbornene Catalysis
• 4 Directing Group Assisted meta‐C–H Functionalization of Arenes Aided by Norbornene as Transient Mediator
• 5 Ruthenium‐Catalyzed Remote C–H Functionalizations
• 6 Harnessing Non‐covalent Interactions for Distal C(sp2)–H Functionalization of Arenes
• 7 The Non‐directed Distal C(sp2)–H Functionalization of Arenes
• 8 Transition Metal Catalyzed Distal para‐Selective C–H Functionalization
• 9 Regioselective C–H Functionalization of Heteroaromatics at Unusual Positions
• 10 Directing Group Assisted Distal C(sp3)–H Functionalization of Aliphatic Substrates
• 11 Radically Initiated Distal C(sp3)–H Functionalization
• 12 Non‐Directed Functionalization of Distal C(sp3)H Bonds
• 13 Remote Oxidation of Aliphatic CH Bonds with Biologically Inspired Catalysts
• Index
• End User License Agreement