Dynamic Combinatorial Chemistry

In Drug Discovery, Bioorganic Chemistry, and Materials Science

Benjamin L. Miller

• Publisher: Wiley
• Year: 2009
• Print ISBN: 9780470096031
• eBook ISBN: 9780470551547
• Edition: 1
• Topic: Physical Sciences
• Subtopic: Physical & Theoretical Chemistry

Effective techniques for applying Dynamic Combinatorial Chemistry

In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others. Bringing together a group of respected experts, this overview explains how chemists can apply DCC and fragment-based library methods to lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science.

Chapters cover:

• Basic theory

• Approaches to binding in proteins and nucleic acids

• Molecular recognition

• Self-sorting

• Catalyst discovery

• Materials discovery

• Analytical chemistry challenges

A comprehensive, single-source reference about DCC methods and applications including aspects of fragment-based drug discovery, this is a core reference that will spark the development of new solutions and strategies for chemists building structure libraries and designing compounds and materials.

Table of contents

• Dynamic Combinatorial Chemistry