Toxicology and Epigenetics
eBook - PDF

Toxicology and Epigenetics

  1. English
  2. PDF
  3. Available on iOS & Android
eBook - PDF

Toxicology and Epigenetics

About this book

Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical.

Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research.

Topics covered include:

  • environment, epigenetics and diseases
  • DNA methylation and toxicogenomics
  • chromatin at the intersection of disease and therapy
  • epigenomic actions of environmental arsenicals
  • environment, epigenetics and cardiovascular health
  • toxicology, epigenetics and autoimmunity
  • ocular epigenomics: potential sites of environmental impact in development and disease
  • nuclear RNA silencing and related phenomena in animals
  • epigenomics – impact for drug safety sciences
  • methods of global epigenomic profiling
  • transcriptomics: applications in epigenetic toxicology

Toxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.

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Yes, you can access Toxicology and Epigenetics by Saura C. Sahu in PDF and/or ePUB format, as well as other popular books in Physical Sciences & Industrial & Technical Chemistry. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Wiley
Year
2012
Print ISBN
9781119976097
eBook ISBN
9781118349038
Edition
1
Topic
Physical Sciences
Subtopic
Industrial & Technical Chemistry

Table of contents

  1. Toxicology and Epigenetics
  2. Contents
  3. Preface
  4. Acknowledgments
  5. List of Contributors
  6. Chapter 1 Introduction
  7. Chapter 2 Environment, Epigenetics, and Diseases
  8. Chapter 3 DNA Methylation and Toxicogenomics
  9. Chapter 4 Chromatin at the Intersection of Disease and Therapy
  10. Chapter 5 Molecular Epigenetic Changes Caused by Environmental Pollutants
  11. Chapter 6 Epigenetic Mediation of Environmental Exposures to Polycyclic Aromatic Hydrocarbons
  12. Chapter 7 Epigenomic Actions of Environmental Arsenicals
  13. Chapter 8 Arsenic-Induced Changes to the Epigenome
  14. Chapter 9 Environmental Epigenetics, Asthma, and Allergy: Our Environment's Molecular Footprints
  15. Chapter 10 miRNAs in Human Prostate Cancer
  16. Chapter 11 Environment, Epigenetics, and Cardiovascular Health
  17. Chapter 12 Toxicology, Epigenetics, and Autoimmunity
  18. Chapter 13 Toxicoepigenomics in Lupus
  19. Chapter 14 Ocular Epigenomics: Potential Sites of Environmental Impact in Development and Disease
  20. Chapter 15 Nuclear RNA Silencing and Related Phenomena in Animals
  21. Chapter 16 Epigenetic Biomarkers in Cancer Detection and Diagnosis
  22. Chapter 17 Epigenetic Histone Changes in the Toxicologic Mode of Action of Arsenic
  23. Chapter 18 Irreversible Effects of Diethylstilbestrol on Reproductive Organs and a Current Approach for Epigenetic Effects of Endocrine Disrupting Chemicals
  24. Chapter 19 Epigenomics-Impact for Drug Safety Sciences
  25. Chapter 20 Archival Toxicoepigenetics: Molecular Analysis of Modified DNA from Preserved Tissues in Toxicology Studies
  26. Chapter 21 Nanoparticles and Toxicoepigenomics
  27. Chapter 22 Methods of Global Epigenomic Profiling
  28. Chapter 23 Transcriptomics: Applications in Epigenetic Toxicology
  29. Chapter 24 Carcinogenic Metals Alter Histone Tail Modifications
  30. Chapter 25 Prediction of Epigenetic and Stochastic Gene Expression Profiles of Late Effects after Radiation Exposure
  31. Chapter 26 Modulation of Developmentally Regulated Gene Expression Programs through Targeting of Polycomb and Trithorax Group Proteins
  32. Chapter 27 Chromatin Insulators and Epigenetic Inheritance in Health and Disease
  33. Chapter 28 Bioinformatics for High-Throughput Toxico-Epigenomics Studies
  34. Chapter 29 Computational Methods in Toxicoepigenomics
  35. Chapter 30 Databases and Tools for Computational Epigenomics
  36. Chapter 31 Interface of Epigenetics and Carcinogenic Risk Assessment
  37. Chapter 32 Epigenetic Modifications in Chemical Carcinogenesis
  38. Chapter 33 Application of Cancer Toxicoepigenomics in Identifying High-Risk Populations
  39. Author Index
  40. Subject Index