eBook - ePub
Pathology of Melanocytic Tumors E-Book
Klaus J. Busam, Richard A Scolyer, Pedram Gerami
This is a test
Share book
- 608 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
eBook - ePub
Pathology of Melanocytic Tumors E-Book
Klaus J. Busam, Richard A Scolyer, Pedram Gerami
Book details
Book preview
Table of contents
Citations
About This Book
Constituting a large percentage of everyday diagnostic practice, melanocytic pathology is a complex and challenging area with many difficult-to-diagnose lesions. This highly illustrated reference, written by three of the world's leading dermatopathologists, provides authoritative guidance in the accurate diagnosis of even the most challenging pigmented skin tumors, helping you avoid pitfalls and recognize mimics.
- Covers nearly every variant of melanocytic tumors you're likely to see.
- Emphasizes how to arrive at an efficient, accurate diagnosis, and includes dermoscopic findings for optimal diagnostic precision.
- Discusses modern analytic techniques ( cytogenetics, molecular studies ) and how to use them for diagnosis.
- Includes numerous case examples to illustrate the differential diagnoses and work-up; how to use ancillary techniques, along with their pros, cons, and limitations; and clinical follow-up.
- Presents the knowledge and experience of Klaus Busam, Pedram Gerami, and Richard Scolyer, ā three dermatopathologists who are globally renowned for their expertise in melanoma pathology and analysis of melanocytic tumors by modern ancillary diagnostic techniques.
Frequently asked questions
How do I cancel my subscription?
Can/how do I download books?
At the moment all of our mobile-responsive ePub books are available to download via the app. Most of our PDFs are also available to download and we're working on making the final remaining ones downloadable now. Learn more here.
What is the difference between the pricing plans?
Both plans give you full access to the library and all of Perlegoās features. The only differences are the price and subscription period: With the annual plan youāll save around 30% compared to 12 months on the monthly plan.
What is Perlego?
We are an online textbook subscription service, where you can get access to an entire online library for less than the price of a single book per month. With over 1 million books across 1000+ topics, weāve got you covered! Learn more here.
Do you support text-to-speech?
Look out for the read-aloud symbol on your next book to see if you can listen to it. The read-aloud tool reads text aloud for you, highlighting the text as it is being read. You can pause it, speed it up and slow it down. Learn more here.
Is Pathology of Melanocytic Tumors E-Book an online PDF/ePUB?
Yes, you can access Pathology of Melanocytic Tumors E-Book by Klaus J. Busam, Richard A Scolyer, Pedram Gerami in PDF and/or ePUB format, as well as other popular books in Medizin & Pathologie. We have over one million books available in our catalogue for you to explore.
Information
Topic
MedizinSubtopic
PathologieSection I
Benign Cutaneous Melanocytic Proliferations
Introduction
- 1. Melanotic Macules, 2
- Klaus J. Busam
- 2. Acquired Melanocytic Nevi, 8
- Pedram Gerami and Klaus J. Busam
- 3. Congenital Melanocytic Nevi, 26
- Pedram Gerami
- 4. Spitz Nevi, 37
- Pedram Gerami and Klaus J. Busam
- 5. Blue Nevi and Dermal Melanocytosis, 61
- Klaus J. Busam
- 6. Deep Penetrating Nevi, 80
- Klaus J. Busam, Iwei Yeh, and Richard A. Scolyer
- 7. Melanocytic Nevi of Special Sites, 90
- Timothy VandenBoom and Pedram Gerami
- 8. Persistant/Recurrent Melanocytic Nevi, Traumatized Nevi, and Nevi Changing Under Therapy, 101
- Maija Kiuru, Pedram Gerami, and Klaus J. Busam
- 9. Combined Melanocytic Nevi, 112
- Klaus J. Busam and Richard A. Scolyer
- 10. Pigmented Epithelioid Melanocytoma, 124
- Artur Zembowicz, Jarish N. Cohen, and Philip E. LeBoit
1
Melanotic Macules
Klaus J. Busam
The term melanotic macule is used to refer to benign flat pigmented lesions, which are histopathologically characterized by melanin pigment deposited in basilar keratinocytes without or at times with a slight increase in the density of solitary units of junctional melanocytes. Cutaneous and mucosal melanotic macules are often labeled lentigo. The conjunctival equivalent has historically been termed acquired melanosis. In contrast to melanocytic nevi, there are no junctional nests in melanotic macules, lentigines, or benign acquired melanosis. The lesions differ from melanoma in situ clinically by a tendency toward small size and sharp circumscription and histopathologically by a low density of melanocytes. Melanotic macules are a common clinical presentation. They are benign and do not need to be treated. However, they may be biopsied when they display irregular features, are new, or are changing, to exclude melanoma in situ.
Solar Lentigo
Clinical Features
Solar lentigo manifests as a discrete pigmented macule or patch on sun-exposed skin of middle-aged or elderly individuals (Box 1.1).1 Its color may range from light tan to dark brown. A lesion's color may be uniform or heterogeneous. The size of a solar lentigo may be small (2 mm) or large (>1 cm). Its peripheral borders may be regular or ill-defined (Figs. 1.1 and 1.2). Multiple lesions of solar lentigo may coexist in the same anatomic region. They may collide with each other or with seborrheic or actinic keratoses, become confluent, and appear clinically complex. Clinical atypical lesions, which stand out from the background, prompt concerns for lentigo maligna (melanoma in situ) and are usually biopsied to assess for or exclude melanoma. Solar lentigines become more frequent and/or larger in area with age. Lesions of solar lentigo can also be found in young patients with sun-damaged skin and are common in children with xeroderma pigmentosum.
A variant of solar lentigo clinically characterized by presentation as small dark macules, especially on the upper back, has been referred to as āink spotā lentigo or reticulated melanotic macule.2
Histopathologic Findings
Solar lentigo is histopathologically characterized by hypermelanization of basilar keratinocytes (Figs. 1.3ā1.5). Often there is associated slight epidermal hyperplasia resulting in elongated, club-shaped rete ridges. As rete ridges become longer, they may form a reticulate pattern. Lesions of solar lentigo may be associated with or develop into a seborrheic keratosis (Fig. 1.6). Pigmentation of keratinocytes is then typically most pronounced at the tip of rete ridges. In some lesions the rete ridges may...