eBook - ePub
Diagnostic Atlas of Cutaneous Mesenchymal Neoplasia E-Book
- 736 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
eBook - ePub
Diagnostic Atlas of Cutaneous Mesenchymal Neoplasia E-Book
About this book
With its many diagnostic categories, relevant variants, and rare tumors, soft tissue pathology is one of the most challenging areas of surgical pathology. Focusing on the cutaneous soft tissue specimens and reactive mimics most likely to be encountered by pathologists and dermatopathologists, Diagnostic Atlas of Cutaneous Mesenchymal Neoplasia is a superbly illustrated, easy-to-use atlas designed to be used beside the microscope for efficient diagnosis and classification of soft tissue tumors of the skin.- Features high-quality histologic and clinical images of multiple examples of each tumor, with captions and bulleted text for quick reference.- Uses a high-yield format that facilitates a rapid and accurate diagnosis, including: - Characteristic clinical setting- Key morphologic features- Immunohistochemical properties- Molecular diagnostic testing (where applicable)- Offers the most complete presentation available of this complex family of tumors, authored by renowned experts in dermatopathology.
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Please note we cannot support devices running on iOS 13 and Android 7 or earlier. Learn more about using the app.
Yes, you can access Diagnostic Atlas of Cutaneous Mesenchymal Neoplasia E-Book by J. Eduardo Calonje,Alexander J Lazar,Bostjan Luzar in PDF and/or ePUB format, as well as other popular books in Medicine & Pathology. We have over one million books available in our catalogue for you to explore.
Information
1
Adipocytic tumors
Benign tumors and reactive conditions
Lipoma
Definition
- • A benign dermal or subcutaneous mesenchymal tumor composed of mature adult-type adipose tissue
Clinical features
Epidemiology
- • The most commonly encountered mesenchymal tumor
- • Majority of patients are adults
- • No sex predilection
Presentation
- • Most cases are asymptomatic
- • Occasionally painful when compressing nerves
- • Slowly growing, but size is variable
- • Usually solitary
- • Multiple lipomas may be associated with neurofibromatosis, multiple endocrine neoplasia syndromes, or Bannayan syndrome (hemangiomas and multiple lipomas)
Prognosis and treatment
- • Treated mostly for aesthetic reasons
- • Cured by conservative surgical excision
- • Recur only if incompletely excised and then only rarely
- • Not associated with progression to liposarcoma
Pathology
Histology
- • Resemble normal adult-type adipose tissue
- • Lobules of adipocytes bounded by thin fibrous septa
- • Adipocytes have large single lipid vacuole in their cytoplasm and eccentrically located small nuclei
- • May show areas of fat necrosis and increased fibrosis after trauma
- • No atypia, pleomorphism, mitoses, or hyperchromasia
Immunohistochemistry/special stains
- • Adipocytes express S100 protein
Genetic profile
- • True neoplasms
- • Translocation at 12q14 involving HMGA2 gene is the most common aberration, often with LPP (3q27)
- • 6p21-23 rearrangements involving HMG1B gene are also seen
Main differential diagnoses
- • Normal adipose tissue
- • Pseudolipomatosis cutis
- • Atypical lipomatous tumor
Fig. 1 Lipoma. Deeper lipomas are well-circumscribed neoplasms composed of mature adipose tissue essentially indistinguishable from normal fat.
Fig. 2 Lipoma. High-power view of mature adipocytes exhibiting minimal size variatio...
Table of contents
- Cover image
- Title Page
- Table of Contents
- Copyright
- Preface
- Acknowledgements
- Dedication
- 1 Adipocytic tumors
- 2 Fibroblastic and myofibroblastic tumors of the skin
- 3 Fibrohistiocytic tumors
- 4 Cutaneous smooth muscle tumors
- 5 Pericytic (perivascular) tumors
- 6 Skeletal Muscle Tumors
- 7 Tumors of vascular origin
- 8 Bone- and cartilage-forming tumors and tumors of joints
- 9 Tumors of neuroectodermal origin
- 10 Miscellaneous Tumors of Uncertain Differentiation
- Index