Nanotechnology has the potential to change every part of our lives. Today, nanotechnology-based products are used in many areas, and one of the most important areas is drug delivery. Nanoparticulate drug delivery systems not only provide controlled delivery of drugs and improved drug solubility but also improve drug efficiency and reduce side effects via targeting mechanisms. However, compared with conventional drug delivery systems, few nanoparticle-based products are on the market and almost all are nontargeted or only passively targeted systems. In addition, obtaining targeted nanoparticle systems is quite complex and requires several evaluation mechanisms. This book discusses the production, characterization, regulation, and currently marketed targeted nanoparticle systems in a broad framework. It provides an overview of targeted nanoparticles' (i) in vitro characterization, such as particle size, stability, ligand density, and type; (ii) in vivo behavior for different targeting areas, such as tumor, brain, and vagina; and (iii) current advances in this field, including clinical trials and regulation processes.

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Yes, you can access Drug Delivery with Targeted Nanoparticles by Yılmaz Çapan, Adem Sahin, Hayrettin Tonbul, Adem Sahin,Hayrettin Tonbul,Yılmaz Çapan in PDF and/or ePUB format, as well as other popular books in Medicine & Biotechnology in Medicine. We have over one million books available in our catalogue for you to explore.

Information

Publisher

Jenny Stanford Publishing

Year

2021

Print ISBN

9789814877756

eBook ISBN

9781000375305

Edition

Topic

Medicine

Subtopic

Biotechnology in Medicine

Cover Page
Half-Title Page
Title Page
Copyright Page
Table of Contents
Preface
1. Particle Size Determination of Targeted Nanoparticles
2. Zeta Potential Determination of Targeted Nanoparticles
3. Stability of Targeted Nanoparticles
4. Impact of PEGylation on Targeted Nanoparticulate Delivery
5. Ligands and Receptors for Targeted Delivery of Nanoparticles: Recent Updates and Challenges
6. Characterization of Biological Molecule—Loaded Nanostructures Using Circular Dichroism and Fourier Transform Infrared Spectroscopy
7. Evaluation of Stimuli-Sensitive Nanoparticles in vitro
8. Analytical Techniques for Characterization of Nanodrugs
9. Cytotoxicity and Biological Compatibility
10. Cellular Uptake and Transcytosis
11. Evaluation of 3D Cell Culture Models for Efficacy Determination of Anticancer Nanotherapeutics
12. In vitro and in vivo Blood–Brain Barrier Models for the Evaluation of Drug Transport with Targeted Nanoparticles
13. Sterility Evaluation of Targeted Nanoparticles
14. Evaluation of Pharmacokinetics and Biodistribution of Targeted Nanoparticles
15. Evaluation of the in vivo Preclinical Toxicity of Targeted Nanoparticles
16. Transdermal Delivery of Targeted Nanoparticles and in vitro Evaluation
17. In vivo and in vitro Evaluation of Nose-to-Brain Delivery of Nanoparticles
18. Evaluation of Targeted Nanoparticles for Ocular Delivery
19. Vaginally Applied Nanocarriers and Their Characterizatons
20. Oral Administration of Nanoparticles and Approaches for Design, Evaluation, and State of the Art
21. Drug Resistance Mechanisms and Strategies to Overcome Drug Resistance with Nanoparticulate Systems
22. Clinical Trials of Targeted Nanoparticulate Drug Delivery Systems
23. Evaluation of Targeted Mesoporous Silica Nanoparticles
24. Evaluation of Targeted Liposomes
25. Prospects of Nanomedicine with Nanocrystal Technology
26. Characteristics of Marketed Nanopharmaceutics
27. Regulatory Guidelines of the US Food and Drug Administration and the European Medicines Agency for Actively Targeted Nanomedicines
Index

About this book

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Table of contents