Drug Delivery with Targeted Nanoparticles

In Vitro and In Vivo Evaluation Methods

Yılmaz Çapan, Adem Sahin, Hayrettin Tonbul, Adem Sahin, Hayrettin Tonbul, Yılmaz Çapan

• Publisher: Jenny Stanford Publishing
• Year: 2021
• Print ISBN:
  9789814877756
• eBook ISBN:
  9781000375305
• Topic: Medicine
• Subtopic: Biotechnology in Medicine

Nanotechnology has the potential to change every part of our lives. Today, nanotechnology-based products are used in many areas, and one of the most important areas is drug delivery. Nanoparticulate drug delivery systems not only provide controlled delivery of drugs and improved drug solubility but also improve drug efficiency and reduce side effects via targeting mechanisms. However, compared with conventional drug delivery systems, few nanoparticle-based products are on the market and almost all are nontargeted or only passively targeted systems. In addition, obtaining targeted nanoparticle systems is quite complex and requires several evaluation mechanisms. This book discusses the production, characterization, regulation, and currently marketed targeted nanoparticle systems in a broad framework. It provides an overview of targeted nanoparticles' (i) in vitro characterization, such as particle size, stability, ligand density, and type; (ii) in vivo behavior for different targeting areas, such as tumor, brain, and vagina; and (iii) current advances in this field, including clinical trials and regulation processes.

Table of contents

• Cover Page
• Half-Title Page
• Title Page
• Copyright Page
• Table of Contents
• Preface
• 1. Particle Size Determination of Targeted Nanoparticles
• 2. Zeta Potential Determination of Targeted Nanoparticles
• 3. Stability of Targeted Nanoparticles
• 4. Impact of PEGylation on Targeted Nanoparticulate Delivery
• 5. Ligands and Receptors for Targeted Delivery of Nanoparticles: Recent Updates and Challenges
• 6. Characterization of Biological Molecule—Loaded Nanostructures Using Circular Dichroism and Fourier Transform Infrared Spectroscopy
• 7. Evaluation of Stimuli-Sensitive Nanoparticles in vitro
• 8. Analytical Techniques for Characterization of Nanodrugs
• 9. Cytotoxicity and Biological Compatibility
• 10. Cellular Uptake and Transcytosis
• 11. Evaluation of 3D Cell Culture Models for Efficacy Determination of Anticancer Nanotherapeutics
• 12. In vitro and in vivo Blood–Brain Barrier Models for the Evaluation of Drug Transport with Targeted Nanoparticles
• 13. Sterility Evaluation of Targeted Nanoparticles
• 14. Evaluation of Pharmacokinetics and Biodistribution of Targeted Nanoparticles
• 15. Evaluation of the in vivo Preclinical Toxicity of Targeted Nanoparticles
• 16. Transdermal Delivery of Targeted Nanoparticles and in vitro Evaluation
• 17. In vivo and in vitro Evaluation of Nose-to-Brain Delivery of Nanoparticles
• 18. Evaluation of Targeted Nanoparticles for Ocular Delivery
• 19. Vaginally Applied Nanocarriers and Their Characterizatons
• 20. Oral Administration of Nanoparticles and Approaches for Design, Evaluation, and State of the Art
• 21. Drug Resistance Mechanisms and Strategies to Overcome Drug Resistance with Nanoparticulate Systems
• 22. Clinical Trials of Targeted Nanoparticulate Drug Delivery Systems
• 23. Evaluation of Targeted Mesoporous Silica Nanoparticles
• 24. Evaluation of Targeted Liposomes
• 25. Prospects of Nanomedicine with Nanocrystal Technology
• 26. Characteristics of Marketed Nanopharmaceutics
• 27. Regulatory Guidelines of the US Food and Drug Administration and the European Medicines Agency for Actively Targeted Nanomedicines
• Index