Toxicology for the Health and Pharmaceutical Sciences
Antonio Peña-Fernández, Mark D. Evans, Marcus S. Cooke, Antonio Peña-Fernández, Mark D. Evans, Marcus S. Cooke
- 512 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
Toxicology for the Health and Pharmaceutical Sciences
Antonio Peña-Fernández, Mark D. Evans, Marcus S. Cooke, Antonio Peña-Fernández, Mark D. Evans, Marcus S. Cooke
About This Book
There is an increasing need for knowledge of toxicology to safeguard the use of chemicals in industry and in the public and private sectors. The study of toxicology is becoming increasingly relevant in human health sciences, as future health and clinical professionals will be pivotal in addressing and managing emerging chemical threats and hazards related to modern anthropogenic activities and technological development.
Comprising a series of chapters from leading toxicology, pharmacy and public health academics and experts across Europe, the United States and beyond, Toxicology for the Health and Pharmaceutical Sciences provides a concise yet comprehensive volume that can be used as a relevant textbook on toxicology for the clinical, healthcare, educational and professional sectors.
Key Features:
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- Includes cutting edge information regarding the very lastest environmental threats to public health
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- Provides a detailed case study based on a real-world scenario that allows the reader to practice human health risk assessment
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- Describes innovative guidance and tools to respond to chemical incidents and attacks, which enables the reader to tailor an effective protection and remediation response
This book covers the fundamentals and recent developments in toxicology, to respond to local and global chemical, pharmaceutical and environmental threats. Thus, this volume has chapters specifically designed to support the understanding of the most current toxicology-related subjects for any undergraduate/postgraduate health programs as well as aid the delivery of continuing professional development training on up-to-date topics in toxicology for current practicing health professionals wishing to improve their background knowledge in toxicology. The book is also vital reading and reference for policy makers and others that influence and set regulations that have an impact on the environment and human health.
Frequently asked questions
Information
1
Introduction to Toxicology
CONTENTS
1.1 THE CONCEPT OF TOXICOLOGY AND AREAS OF ACTION
- General: the general basis of toxic actions. This includes mechanisms of action and ways of counteracting their effects.
- Descriptive: the science of toxicity testing to provide information about safety evaluation and regulatory requirements. The different aspects and toxicological studies are grouped on toxic agents such as metal toxicology, toxicology of organic solvents, toxicology of pesticides and so forth.
- Mechanistic: studies, identifies and attempts to understand the mechanisms by which toxic agents exert toxic effects on living beings, in order to produce safer substances and develop a rational treatment of intoxication.
- Regulatory: integrates the information obtained from the mechanistic and descriptive areas to determine the level of risk to health and to the handling of exposure to chemical substances.
- Vertical integration gives rise to the appearance of diverse subdisciplines: genetic, molecular toxicology, inmunotoxicology, neurotoxicology and so forth.
- Horizontal integration is oriented towards practical applications with repercussions that affect the environment and human health. In this way, two areas appear:
- Retrospective toxicology: typical of the forensic branch oriented to the investigation of a toxin in corporal organs and its medicolegal aspects.
- Predictive toxicology: oriented towards the prediction of possible toxic effects in specific situations, including drug use, drug interactions and presence of contaminants or additives not allowed in food.
- Clinical toxicology, based on physiology, clinical chemistry and pharmacology, which studies the pathological changes caused by toxic agents, establishes treatments for intoxicated patients and analyzes new techniques to treat intoxications.
- Occupational or professional toxicology, based on occupational medicine and occupational hygiene. Occurrence of occupational diseases is related to toxic substances present in work environments. Therefore, toxicology investigates the harmful effects produced by substances for occupational use and determines safe exposure limits.
- Environmental toxicology, which relies on ecology and environmental chemistry to analyze the impact of pollutants present in the environment of living organisms. It is the subdiscipline responsible for evaluating the vast environmental impact produced by exposures to chemical products present in the environment, with special attention to living species other than humans in air, soil or water. A complex environment requires paying attention to the persistence of pollutants in soil, water and air, and knowing the capacity they have to join the food chain.
- Food toxicology is a multidisciplinary approach, studying adverse effects of exposure by living organisms to chemical substances present in food. This area is supported by chemical analysis, food science and nutrition.It is important to know what products are safe to eat, and in what amounts; this discipline investigates the safety of the components that are added to food, deliberately or accidentally, as natural and synthetic additives or contaminants. Accidental contaminants are generally synthetic or natural environmental contaminants, such as polychlorinated biphenyls (PCBs) and methylmercury, which are found in fish; microbial toxins such as those produced by Escherichia coli in contaminated food; and fungal toxins, such as aflatoxins, which can contaminate grains. Recently, scientists have investigated and debated about the safety of genetically modified organisms (GMOs) as food products and the influence of new conservation technologies on food safety.
- Pharmacological toxicology studies the safety of pharmaceutical products. Toxicity testing helps ensure that pharmaceutical products are safe for humans. Advances in pharmacology and toxicological research help to ensure that the beneficial effects of therapeutic agents are not outweighed by undesired side effects.
- Forensic toxicology establishes the causes of death caused by toxins in humans and animals, their circumstances, and their medicolegal implications.