Multiphase Biomedical Materials

T. Tsuruta, A. Nakajima, Tsuruta, Nakajima

• Publisher: CRC Press
• Year: 2021
• Print ISBN: 9789067641098
• eBook ISBN: 9781000557589
• Edition: 1
• Topic: Physical Sciences
• Subtopic: Chemistry
• Index: Chemistry

Following many reports that were published in the last two decades on correlations of multiphase structures of the surface of materials with their antithrombogenicity or biocompatibility a research project ''Design of Multiphase Biomedical Materials'' was carried out in Japan between 1982 and 1986. The objective of this research project was to elucidate various aspects of biomedical behaviour of multiphase systems at the interface with living bodies at the molecular, cellular and tissue levels. Multiphase materials studied cover polymers having microphase-separated structures, hydrogels, immobilized enzymes (or cells), ceramics and metallic materials. The research project was carried out by the following subgroups: -- Multiphase biomedical materials with microdomain structures -- Multiphase biomedical materials containing liquid components -- Hybrid-type multiphase biomedical materials with biological components -- Inorganic and metallic multiphase biomedical materials -- Methods for analysis and evaluation of multiphase biomedical materials This book contains the results of the research project in an edited form and aims to provoke a better understanding about various aspects of cell--material interactions in which the multiphase systems play a crucial role.

Preface

Since microheterogeneity (Y. Imai and E. Masuhara) or micro-architecture (D. J. Lyman) of the surface of materials was seen as playing an important role in determining the mode of cell material interactions, there were quite a few reports presented in the 1970s and 1980s suggesting correlations of multiphase structures of the surface of materials with their antithrombogenicity or biocompatibility.

A Special Research Project 'Design of Multiphase Biomedical Materials', which was supported by the Japanese Ministry of Education, Science and Culture, was promoted between 1982 and 1986 in Japan under interdisciplinary cooperation among researchers in materials science and the biological and medical sciences. The objective of this research project was to elucidate various aspects of biomedical behavior of multiphase systems at the interface with living bodies at the molecular, cellular and tissue levels. Multiphase materials studied in the research project cover polymers having microphase-separated structures, hydrogels, immobilized enzymes (or cells), ceramics, and metallic materials.

The research project was carried out by five subgroups: (I) multiphase biomedical materials with microdomain structures; (II) multiphase biomedical materials containing liquid components; (III) hybrid-type multiphase biomedical materials with biological components; (IV) inorganic and metallic multiphase biomedical materials; and (V) methods for analysis and evaluation of multiphase biomedical materials.

Thanks to the great efforts made by members of the research project, a marked progress of basic and applied studies has been achieved in the field of biomaterials science and technology. Especially, new concepts obtained in the course of the research project are now exploring new frontiers and innovations in the expanding world of biomaterials.

This book was edited to provoke a better understanding about various aspects of cell-material interactions in whch the multiphase systems play a crucial role. The contents are organized by selecting eleven high-light researches from the five subgroups as follows:

Chapters	1	2	3	4	5	6	7	8	9	10	11
Subgroups	I, V	I	II	V	III	III	IV	IV	III	III	II

Each writer of the ten chapters describes the results of his own research, featuring the objectives and characteristics of the subgroup project.

The Editors express their sincere acknowledgment to the Japanese Ministry of Education, Science and Culture, for its support to the Special Research Project, which brought about fruitful results and motivated us to edit this book in order to provoke international recognition of the importance of multiphase biomedical materials.

T. Tsuruta and A. Nakajima
Editors

Chapter 1 Controlled interactions of cells with multiphase-structured surfaces of block and graft copolymers

DOI: 10.1201/9780429087592-1

KAZUNORI KATAOKA,*¹ TERUO OKANO,¹ YASUHISA SAKURAI,¹ ATSUSHI MARUYAMA†,² and TEIJI TSURUTA²

¹Institute of Biomedical Engineering, Tokyo Women's Medical College, 8-1 Kawada, Shinjuku, Tokyo 162, Japan

²Department of Industrial Chemistry, Science University of Tokyo, Kagurazaka, Shinjuku, Tokyo 162, Japan

* Present address: Department of Materials Science and Research Institute for Biosciences, Science University of Tokyo, Noda, Chiba 278, Japan

† Present address: Department of Chemistry, Sophia University, Kioi-cho, Chiyoda-ku, Tokyo 102, Japan.

Summary—Detailed studies on cell-material interaction greatly facilitate the molecular design of materials having a regulative effect on cellular functions. These type of materials will have novel applications in the diverse field of biomedical sciences and technologies. This paper reviews the promising features of microdomain-structured polymers as materials capable of regulating several cellular functions. Particular emphasis is placed on the successful utilization of these microdomain-structured polymers as innovative biofunctionality materials such as non-thrombogenic materials and cell-specific adsorbents.

1. INTRODUCTION

Recently, cellular behavior at material interfaces has received a great deal of interest from many researchers in the field of biomaterials science. A principal motivation of this inter...

Table of contents

• Cover Page
• Half Title Page
• Series Page
• Title Page
• Copyright Page
• Contents Page
• Preface Page