eBook - PDF

Neurobiological Mechanisms of Bipolar Disorder

Name: Neurobiological Mechanisms of Bipolar Disorder
ISBN: 9786202222082

Investigated in a virus-induced Animal Model

Dominik Beyer,

84 pages
English
PDF
Available on iOS & Android

eBook - PDF

Neurobiological Mechanisms of Bipolar Disorder

Investigated in a virus-induced Animal Model

Dominik Beyer,

About this book

Bipolar disorder is characterized by a switch between manic and depressive episodes. Recently, Freund and colleagues developed a lentiviral-induced animal model that is able to model both phases in one animal. By manipulating the dopamine D1 receptor (D1R) expression in the medial prefrontal cortex (mPFC) of rats, they were able to induce either mania- or depressive-like behavior one after the other. Lentiviral overexpression of the D1R in rats PFC induced mania-like behavior (ON state), whereas termination of this D1R overexpression (OFF state) resulted in depressive-like behavior. For a better understanding of the neurobiology connected to the observed behavior, this study investigated dopamine D2 receptor (D2R) alterations in the rat brain accompanied by induced mania- or depressive-like behavior. To obtain a first insight view on the impact of this D1R manipulation, the D2R properties were examined as a possible downstream target in several bipolar associated brain regions, like the PFC, striatum, nucleus accumbens, hippocampus and ventral tegmental area.

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Yes, you can access Neurobiological Mechanisms of Bipolar Disorder by Dominik Beyer in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Biology. We have over one million books available in our catalogue for you to explore.