DNA Origami

Structures, Technology, and Applications

Masayuki Endo

• Publisher: Wiley
• Year: 2022
• Print ISBN: 9781119682547
• eBook ISBN: 9781119682578
• Edition: 1
• Topic: Technology & Engineering
• Subtopic: Nanotechnology & MEMS
• Index: Technology & Engineering

DNA ORIGAMI

Discover the impact and multidisciplinary applications of this subfield of DNA nanotechnology

DNA origami refers to the technique of assembling single-stranded DNA template molecules into target two- and three-dimensional shapes at the nanoscale. This is accomplished by annealing templates with hundreds of DNA strands and then binding them through the specific base-pairing of complementary bases. The inherent properties of these DNA molecules—molecular recognition, self-assembly, programmability, and structural predictability—has given rise to intriguing applications from drug delivery systems to uses in circuitry in plasmonic devices.

The first book to examine this important subfield, DNA Origami brings together leading experts from all fields to explain the current state and future directions of this cutting-edge avenue of study. The book begins by providing a detailed examination of structural design and assembly systems and their applications. As DNA origami technology is growing in popularity in the disciplines of chemistry, materials science, physics, biophysics, biology, and medicine, interdisciplinary studies are classified and discussed in detail. In particular, the book focuses on DNA origami used for creating new functional materials (combining chemistry and materials science; DNA origami for single-molecule analysis and measurements (as applied in physics and biophysics); and DNA origami for biological detection, diagnosis and therapeutics (medical and biological applications).

DNA Origami readers will also find:

• A complete guide for newcomers that brings together fundamental and developmental aspects of DNA origami technology
• Contributions by a leading team of experts that bring expert views from different angles of the structural developments and applications of DNA origami
• An emerging and impactful research topic that will be of interest in numerous multidisciplinary areas
• A helpful list of references provided at the end of each chapter to give avenues for further study

Given the wide scope found in this groundbreaking work, DNA Origami is a perfect resource for nanotechnologists, biologists, biophysicists, chemists, materials scientists, medical scientists, and pharmaceutical researchers.

Table of contents

• Cover
• Title Page
• Copyright Page
• Contents
• List of Contributors
• Preface
• Chapter 1 DNA Origami Technology: Achievements in the Initial 10 Years
• Chapter 2 Wireframe DNA Origami and Its Application as Tools for Molecular Force Generation
• Chapter 3 Capturing Structural Switching and Self-Assembly Events Using High-Speed Atomic Force Microscopy
• Chapter 4 Advancement of Computer-Aided Design Software and Simulation Tools for Nucleic Acid Nanostructures and DNA Origami
• Chapter 5 Dynamic and Mechanical Applications of DNA Nanostructures in Biophysics
• Chapter 6 Plasmonic Nanostructures Assembled by DNA Origami
• Chapter 7 Assembly of Nanoparticle Superlattices Using DNA Origamias a Template
• Chapter 8 Mechanics of DNA Origami Nanoassemblies
• Chapter 9 3D DNA Origami as Single-Molecule Biophysical Tools for Dissecting Molecular Motor Functions
• Chapter 10 Switchable DNA Origami Nanostructures and Their Applications
• Chapter 11 The Effect of DNA Boundaries on Enzymatic Reactions
• Chapter 12 The Methods to Assemble Functional Proteins on DNA Scaffold and their Applications
• Chapter 13 DNA Origami for Synthetic Biology: An Integrated Gene Logic-Chip
• Chapter 14 DNA Origami for Molecular Robotics
• Chapter 15 DNA origami Nanotechnology for the Visualization, Analysis, and Control of Molecular Events with Nanoscale Precision
• Chapter 16 Stability and Stabilization of DNA Nanostructures in Biomedical Applications
• Chapter 17 DNA Nanostructures for Cancer Diagnosis and Therapy
• Index
• EULA