This first volume chronicles the early stages of the outbreak and world-wide spread of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures. Documenting theepidemiologic response from China, the clinicalevaluation, pathology and intial therapeutics that were availableduring the first 6 months and onwards of the outbreak, this bookrecords how the response to the pandemic was mounted and how various branches of science and research combined to rapidly expand our understanding of the disease.

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Yes, you can access The Coronavirus Pandemic and the Future by Michael D Waters, Alok Dhawan, Tim Marrs, Diana Anderson, Stafford Warren, Claude L Hughes, Michael D Waters,Alok Dhawan,Tim Marrs,Diana Anderson,Stafford Warren,Claude L Hughes in PDF and/or ePUB format, as well as other popular books in Medicine & Infectious Diseases. We have over one million books available in our catalogue for you to explore.

Information

Publisher

Royal Society of Chemistry

Year

2022

Print ISBN

9781839163067

eBook ISBN

9781839163654

Edition

Topic

Medicine

Subtopic

Infectious Diseases

Contents

Volume 1 The Coronavirus Pandemic and the Future: Virology, Epidemiology, Translational Toxicology and Therapeutics

Chapter 1 What We Know About the Life-threatening Novel Human Coronavirus 1

Claude Hughes, Arul Narayanaswamy, Balachandar Vellingiri, Dhivya Venkatesan, Stafford Warren and Michael Waters

1.1 Introduction

1.2 The Chronology of the Outbreak

1.3 Initial Transmission

1.3.1 Worldwide Spread of the Virus

1.4 SARS-CoV-2 and Its Etiology

1.5 Classification and Grouping

1.5.1 Alpha-CoVs

1.5.2 Beta-CoVs

1.5.3 Gamma-CoVs

1.5.4 Delta-CoVs

1.6 Epidemiological History of Human Coronaviruses

1.6.1 Severe Acute Respiratory Syndrome

1.6.2 Middle East Respiratory Syndrome

1.6.3 Detailed Documentation of SARS-CoV-2 and COVID-19 17

1.7 Introductory Virology and Pathophysiology of SARS-CoV-2

1.7.1 Viral Genome

1.7.2 Interaction of the Spike and Receptor for Entry

1.7.3 Genomic Differences

1.7.4 Pathophysiology

1.8 Executive Summary and Conclusions

List of Abbreviations

Acknowledgements

References

Chapter 2 Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): Structure, Lifecycle, and Replication Machinery

Arghadip Samaddar and Vijaya Lakshmi Nag

2.1 Introduction

2.2 Classification of Coronaviruses

2.3 Genomic Structure of SARS-CoV-2

2.4 Life Cycle of SARS-CoV-2

2.4.1 Attachment and Entry

2.4.2 Replicase Protein Expression

2.4.3 Replication and Transcription

2.4.4 Assembly and Release

2.5 SARS-CoV-2 RNA Replication Machinery

References

Chapter 3 Accumulated Epidemiological Lessons and China's COVID-19 Response

Chao Xie and Liangmin Gao

3.1 Introduction

3.2 Accumulated Lessons from China's Response to SARS in 2003

3.3 Epidemiologicial Perspective on China's COVID-19 Response

3.4 China's Control and Prevention Measures in COVID-19

3.4.1 Mask-wearing and its Comforting Effect

3.4.2 Epidemiological Source-tracking and Slow-down of Community Transmission

3.5 Comparing China's Response Against SARS and COVID-19

3.6 Concluding Remarks

3.7 Executive Summary

References

Chapter 4 Clinical Presentation, Pathophysiology and Histopathology

Claude Hughes, Iyer Mahalaxmi, Nachimuthu Senthil Kumar, Suresh Selvapuram Sudalaimuthu Raja, Raviminickam Thangarasu, Stafford Warren and Michael Waters

4.1 Introduction

4.2 The Distinct Clinical Trajectory and Disease Spectrum of COVID-19

4.3 A Novel Application of Smartphone Technology

4.4 COVID-19 and Comorbidities in Severe Cases

4.5 ARDS and its Sequelae in COVID-19

4.5.1 ARDS in COVID-19

4.5.2 Sepsis

4.5.3 Septic Shock

4.6 Pathophysiology

4.6.1 Mechanism of SARS-Cov-2 Invasion into Host Cells

4.7 Histopathology and Disease Manifestations: Introduction

4.7.1 Histopathology

4.7.2 Pulm...

Cover
Half Title
Title
Copyright
Dedication
Foreword
Preface
Volume 1 - Contents
Volume 2 - Contents
Chapter 1 What We Know About the Life-threatening Novel Human Coronavirus
Chapter 2 Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): Structure, Lifecycle, and Replication Machinery
Chapter 3 Accumulated Epidemiological Lessons and China's COVID-19 Response
Chapter 4 Clinical Presentation, Pathophysiology and Histopathology
Chapter 5 Evaluation of the Disease, Sample Collection and Diagnostics
Chapter 6 Therapeutic Options Initially Available for COVID-19 Patients and Initial Clinical Trials
Chapter 7 Clinical Epidemiology of Coronavirus Disease 2019: Infectivity, Clinical Spectrum and Presentation, and Population Distribution
Chapter 8 SARS-CoV-2 Genomics and Host Cellular Susceptibility Factors of COVID-19
Chapter 9 Infection and Pathogenesis of SARS-CoV-2: an Immunological Perspective
Chapter 10 Neurological Manifestations in COVID-19
Chapter 11 COVID-19 and Coagulopathy
Chapter 12 COVID-19 Endocrinopathies: Implications for Care
Chapter 13 Potential Risks of COVID-19 in Reproductive Health
Chapter 14 Clinical Autopsy in COVID-19
Chapter 15 COVID-19 Pharmacotherapy – Present and Future
Chapter 16 Knowledge from Human Relevant Cell, Tissue and Mathematics-based Methods as Key Tools for Understanding COVID-19 Dynamics, Kinetics, Symptoms, Risk Factors and Non-conventional Treatments
Subject Index

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