Hydrogen Sulfide

Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies

Michael D. Pluth, Binghe Wang

• Publisher: Wiley
• Year: 2022
• Print ISBN: 9781119799870
• eBook ISBN: 9781119799894
• Edition: 1
• Topic: Biological Sciences
• Subtopic: Pharmacology
• Index: Biological Sciences

HYDROGEN SULFIDE

Covers H 2 S interactions, methods of detection and delivery in biological environments, and a wide range of applications

Research on hydrogen sulfide (H 2 S) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been developed to deliver H 2 S and related reactive sulfur species in various clinical contexts. Although many biological pathways involving H 2 S are complex, all are governed by fundamental chemical interactions between reactive sulfur species and other molecular entities.

Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies provides the foundation required for understanding the fundamental chemical biology of H 2 S while highlighting the compound's therapeutic potential and medicinal applications. This book covers key aspects of H 2 S chemical biology, including the fundamental chemistry of reactive sulfur species; the measurement, detection, and delivery of H 2 S in biological environments; and the therapeutic and medicinal uses of exogenous H 2 S delivery in various pharmacologically relevant systems. Throughout the text, editor Michael Pluth and chapter contributors discuss the opportunities and future of the multidisciplinary field.

• Provides approaches for delivering H 2 S with relevance to biological and therapeutic applications
• Describes complex interactions of H 2 S with bioinorganic complexes and reactive sulfur, nitrogen, and oxygen species
• Summarizes advances in available tools to detect, measure, and modulate H 2 S levels in biological environments, such as real-time methods for H 2 S fluorescence imaging in live cell and animal systems
• Helps readers understand known systems and make connections to new and undiscovered pathways and mechanisms of action
• Includes in-depth case studies of different systems in which H 2 S plays an important role

Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies is an important source of current knowledge for researchers, academics, graduate students, and industrial scientists in the fields of redox biology, hydrogen sulfide research, and medicinal chemistry of small biological molecules.

Table of contents

• Cover
• Title Page
• Copyright
• Contents
• Preface
• List of Contributors
• Chapter 1 Fundamental and Biologically Relevant Chemistry of H2S and Related Species
• Chapter 2 Signaling by Hydrogen Sulfide (H2S) and Polysulfides (H2Sn) and the Interaction with Other Signaling Pathways
• Chapter 3 Persulfides and Their Reactions in Biological Contexts
• Chapter 4 Hydrogen Sulfide, Reactive Nitrogen Species, and “The Joy of the Experimental Play*”
• Chapter 5 H2S and Bioinorganic Metal Complexes
• Chapter 6 Measurement of Hydrogen Sulfide Metabolites Using the Monobromobimane Method
• Chapter 7 Fluorescent Probes for H2S Detection: Cyclization‐Based Approaches
• Chapter 8 Fluorescent Probes for H2S Detection: Electrophile‐Based Approaches
• Chapter 9 Fluorescent Probes for H2S Detection: Metal‐Based Approaches
• Chapter 10 H2S Release from PS and SeS Motifs
• Chapter 11 Hydrogen Sulfide: The Hidden Player of Isothiocyanates Pharmacology
• Chapter 12 Persulfide Prodrugs
• Chapter 13 COS‐Based H2S Donors
• Chapter 14 Light‐Activatable H2S Donors
• Chapter 15 Macromolecular and Supramolecular Approaches for H2S Delivery
• Chapter 16 H2S and Hypertension
• Chapter 17 H2S Supplementation and Augmentation: Approaches for Healthy Aging
• Chapter 18 Aberrant Hydrogen Sulfide Signaling in Alzheimer's Disease
• Chapter 19 Multifaceted Actions of Hydrogen Sulfide in the Kidney
• Index
• EULA