Genetic Polymorphism and Disease
eBook - ePub

Genetic Polymorphism and Disease

  1. 544 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Genetic Polymorphism and Disease

About this book

Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins.

Key Features

  • Describes the genetic polymorphism and its various types
  • Discusses the role of genetic polymorphisms in modulating the risk of various human diseases
  • Explores various molecular techniques used for detecting GPs
  • Characterizes the role of SNPs in modulating the susceptibility of human diseases
  • Provides a genetic basis for individual variations in response to therapeutics

Frequently asked questions

Yes, you can cancel anytime from the Subscription tab in your account settings on the Perlego website. Your subscription will stay active until the end of your current billing period. Learn how to cancel your subscription.
At the moment all of our mobile-responsive ePub books are available to download via the app. Most of our PDFs are also available to download and we're working on making the final remaining ones downloadable now. Learn more here.
Perlego offers two plans: Essential and Complete
  • Essential is ideal for learners and professionals who enjoy exploring a wide range of subjects. Access the Essential Library with 800,000+ trusted titles and best-sellers across business, personal growth, and the humanities. Includes unlimited reading time and Standard Read Aloud voice.
  • Complete: Perfect for advanced learners and researchers needing full, unrestricted access. Unlock 1.4M+ books across hundreds of subjects, including academic and specialized titles. The Complete Plan also includes advanced features like Premium Read Aloud and Research Assistant.
Both plans are available with monthly, semester, or annual billing cycles.
We are an online textbook subscription service, where you can get access to an entire online library for less than the price of a single book per month. With over 1 million books across 1000+ topics, we’ve got you covered! Learn more here.
Look out for the read-aloud symbol on your next book to see if you can listen to it. The read-aloud tool reads text aloud for you, highlighting the text as it is being read. You can pause it, speed it up and slow it down. Learn more here.
Yes! You can use the Perlego app on both iOS or Android devices to read anytime, anywhere — even offline. Perfect for commutes or when you’re on the go.
Please note we cannot support devices running on iOS 13 and Android 7 or earlier. Learn more about using the app.
Yes, you can access Genetic Polymorphism and Disease by Syed Sameer Aga, Mujeeb Zafar Banday, Saniya Nissar, Syed Sameer Aga,Mujeeb Zafar Banday,Saniya Nissar in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Genetics in Medicine. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. Cover
  2. Half Title
  3. Title Page
  4. Copyright Page
  5. Dedication
  6. Table of Contents
  7. Foreword
  8. Foreword
  9. Preface
  10. Acknowledgments
  11. Editors
  12. Contributors
  13. 1. Genetic Polymorphisms – Classification, Structure, Detection and Function
  14. 2. Clinical Relevance of Pharmacogenomics – a Road to Personalized Medicine
  15. 3. Diabetes and Role of SNPs in Diabetes Susceptibility
  16. 4. Genetic Polymorphisms Associated with Innate Immune Response to Malaria
  17. 5. Xenobiotic Metabolic Enzyme Polymorphisms and Cancer Susceptibility
  18. 6. Genetic Polymorphisms in Matrix Metalloproteinase (MMP) Genes and Cancer
  19. 7. Vitamin D Receptor Polymorphisms and Diseases
  20. 8. Genetic Polymorphisms in Fatty Acid Metabolism Genes and Cancer Susceptibility
  21. 9. Single Nucleotide Polymorphisms and Parkinson’s Disease Susceptibility
  22. 10. Genetic Polymorphisms, Role in Drug Metabolism and Effect on Clinical Pharmacy
  23. 11. Role of Genetic Polymorphisms in Chronic Inflammatory Diseases
  24. 12. Single Nucleotide Polymorphism-Related Computational Resources Part I: Databases
  25. 13. Single Nucleotide Polymorphism-Related Computational Resources Part II: Algorithms
  26. 14. Role of Single Nucleotide Polymorphisms (SNPs) in Common Migraine
  27. 15. The Role of Vitamin D Single Nucleotide Polymorphisms in Cancer Susceptibility
  28. 16. Role of Genetic Polymorphisms in Lipid Metabolism Pathways in Modulating Cancer Promotion
  29. 17. Toll-Like Receptor (TLR) Polymorphisms in Prostate Cancer
  30. 18. Role of Single Nucleotide Polymorphism of Cytochrome P450 Genes in Cancer Susceptibility
  31. 19. Role of Single Nucleotide Polymorphisms of Inflammatory Molecules in Susceptibility to Cardiovascular Diseases (CVDs)
  32. 20. Role of Genetic Polymorphisms in the Etiopathogenesis of Esophageal Cancer
  33. 21. Cytokine Polymorphisms and Their Role in Modulating Cancer Risk
  34. 22. Gastric Cancer and Genetic Polymorphisms in Modulating the Susceptibility
  35. 23. Cytokine Gene Polymorphisms and Their Role in Autoimmune Diseases
  36. 24. Genomic Disturbances Associated with Penile Cancer and Novel Therapies
  37. 25. Role of Genetic Polymorphisms in Gastric Cancer Susceptibility
  38. Index