
- 192 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
About this book
Optogenetics represents a breakthrough technology capable of dynamically modulating molecular and cellular activity in live cells with high precision. This transformative technology made it possible to reversibly interrogate protein actions, cellular events, and animal behaviors with a simple flash of light. Manipulating the temporal and spatial profile of light enabled precise control of membrane potentials. This feature has inspired non-opsin-based optogenetics, which not only inherits the precise spatiotemporal resolution but also expands the targets into a diverse pool of biomolecules such as membrane receptors, ion channels, kinases, GTPases, and transcription factors. This book is unique because it emphasizes the design and applications of opsin-free optogenetic tools.
Key Features
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- Describes new developments in non-opsin-based optogenetic tools
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- Introduces cutting-edge methods for precise modulation of cell signaling
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- Highlights applications of optogenetic regulation of cellular functions
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- Covers contributions from an international team of leading experts
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- Lim, W. & B. Mayer – Cell Signaling (ISBN 9780815342441)
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Information
Table of contents
- Cover
- Half Title
- Series
- Title
- Copyright
- Content
- Preface
- Acknowledgments
- Editor Bios
- List of Contributors
- Chapter 1 Optogenetic Dissection of a Two-Component Calcium Influx Pathway
- Chapter 2 High-Throughput Engineering of a Light-Activatable Ca2+ Channel
- Chapter 3 Optogenetic Activation of TrkB Signaling
- Chapter 4 Spatiotemporal Modulation of Neural Repair
- Chapter 5 Optogenetic Control of Neural Stem Cell Differentiation
- Chapter 6 An Optogenetic Toolbox for Remote Control of Programmed Cell Death
- Chapter 7 Control of Protein Levels in Saccharomyces cerevisiae by Optogenetic Modules that Act on Protein Synthesis and Stability
- Chapter 8 Optogenetics as a Tool to Study Neurodegeneration and Signal Transduction
- Chapter 9 Opsin-free Optogenetics: Brain and Beyond
- Chapter 10 Constructing a Far-Red Light-Induced Split-Cre Recombinase System for Controllable Genome Engineering
- Chapter 11 Tools and Technologies for Wireless and Non-Invasive Optogenetics
- Index