Problem Solving through Precision Oncology

Copson, Ellen R, Hall, Peter, Board, Ruth E, Cook, Gordon, Copson, Ellen R, Hall, Peter, Board, Ruth E, Cook, Gordon

• Publisher: EBN Health
• Year: 2016
• Print ISBN: 9781846921117
• eBook ISBN: 9781846926532
• Topic: Medicine
• Subtopic: Oncology

Precision oncology offers a hugely exciting opportunity to personalise cancer treatments and prevention for the benefit of the individual but does present great challenges at present, both scientific and ethical. We now have the capacity to identify the abnormalities in genes and proteins that introduce the risk of individuals developing cancer and are responsible for the classical behaviour of a cancer. Having done this, healthcare teams are able to better diagnose cancer, evolve preventive strategies, and develop and deploy targeted cancer therapies. Precision oncology involves better prevention strategies and ensuring that therapeutic interventions can be concentrated on those who will benefit, reducing expense and sparing side effects for those who will not. This new educational resource provides an overview of the latest progress in developing precision oncology, plus a ground breaking collection of case studies ("Problems") showing precision oncology in practice. It includes a clear, readable summary of developments, alongside real-life case studies, providing a valuable update for all involved in the oncology community.

Table of contents

• Contents
• Contributors
• Preface
• Acknowledgements
• Abbreviations
• 01 An Introduction to Precision Oncology
• 02 Testicular Cancer: a Successful Model for Biomarker-Guided Precision Cancer Care
• 03 Cancer Susceptibility Genes
• 04 Tumour Biology and Somatic Genetics as They Underpin Precision Oncology
• 05 Pharmacogenomics
• 06 Introducing Next Generation Sequencing into Routine Practice: the Benefits and Challenges
• 07 An Introduction to Proteomics and the Discovery of New Renal Cancer Biomarkers
• 08 Precision Medicine for Multiple Myeloma
• 09 Diffuse Large B Cell Lymphoma
• 10 Stratified Medicine in the UK
• 11 The Economic Challenge of Healthcare Provision in Precision Oncology
• 12 Clinical Trials in Precision Oncology
• 13 Developing Diagnostic Tests for Precision Oncology
• 14 Use of Circulating Tumour-Derived Nucleic Acids in Precision Oncology
• 15 Ethical Issues in Precision Oncology/Cancer Genetics
• 01 A Breast Cancer Patient with a BRCA1 Mutation
• 02 A Patient with DNA Mismatch Repair- Deficient Colorectal Cancer
• 03 A Patient with Advanced Melanoma for Systemic Therapy with a BRAF Inhibitor
• 04 Metastatic Non-Small-Cell Lung Carcinoma with Activating EGFR Mutation
• 05 A Patient with an Advanced Gastrointestinal Stromal Tumour Tested for a KIT Mutation, with Important Drug–Drug Interactions
• 06 A Man with a Mediastinal Sarcoma Receiving Neoadjuvant Therapy
• 07 A Patient with Relapsed Myeloma and High-Risk Cytogenetics
• 08 A Young Man with High-Grade Orbital Lymphoma
• 09 Li–Fraumeni Syndrome
• 10 Von Hippel–Lindau Disease and Renal Cancer
• 11 A Breast Cancer Patient Tested with Oncotype DX
• 12 A Patient with Ovarian Cancer for Whom Treatment Is Guided by Multiplatform Tumour Molecular Profiling
• 13 A Teenager with a Small-Round-Blue- Cell Tumour and a Diagnostic Translocation
• 14 Treatment Based on Clinical Prognostic Factors and Molecular Profiling in Medulloblastoma
• 15 A Patient with Locally Advanced Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma
• 16 A Colorectal Cancer Patient
• 17 A Patient with Advanced Upper Gastrointestinal Cancer and Poor Physical Fitness
• 18 A Patient with Localized Prostate Cancer
• 19 A Patient with BRCA-Mutated Ovarian Cancer
• 20 High-Count T Cell Acute Lymphoblastic Leukaemia with Treatment Stratification Based on Minimal Residual Disease Response
• 21 Application of Cancer Genomics to Routine Care