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Flavonoids and Phenolics
About this book
Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases. This book explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice. Each chapter follows a specific format for a phytochemical agent with common chemical features: • General background on the (phyto)chemistry of the scaffold • General background on the pharmacological profile of the scaffold • A Description of the proposed derivatives and their advantages with respect to the parent compounds (emphasizing the synthetic approaches and structure-activity relationships) • In silico analysis of the crucial interactions with the biological target • Clinical studies and patent survey (if available) on the new and proposed structures The objective of this book set is to fulfil gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.
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Table of contents
- Welcome
- Table of Content
- Title
- BENTHAM SCIENCE PUBLISHERS LTD.
- FOREWORD
- PREFACE
- List of Contributors
- Polyphenols and Flavonoids: Chemical, Pharmacological and Therapeutic Aspects
- Recent Development of Hybrids and Derivatives of Resveratrol in Neurodegenerative Diseases
- Biological Activities of Synthetic Derivatives of Xanthones: An Update (2016-2020)
- Combretastatin Derivatives as Tubulin Inhibitors: A Fascinating Journey from Nature to Drug Discovery Strategies
- Natural Flavonoid and Chalcone Scaffolds as Leads for Synthetic Antitubercular Agents
- In Silico Approaches to Naturally Existing Chalcones and Flavonoids on Mao Inhibitory Action: A Boon to CNS Drug Discovery
- Lignins and Lignans – Recent Developments and Trends Regarding their Pharmaceutical Properties
- Semisynthetic Resveratrol-derived Systems: A Synergism between Nature and Organic Synthesis
- Aurone Scaffold and Structural Analogues for the Development of Monoamine Oxidase (MAO) Inhibitors
- Coumarins as Carbonic Anhydrase Inhibitors
- Phenols and Polyphenols as Carbonic Anhydrase Inhibitors
- The Role of Flavonoids and other Selected (Poly) Phenols in Cancer Prevention and Therapy: A Focus on Epigenetics