Hepatitis C Virus-Host Interactions and Therapeutics: Current Insights and Future Perspectives

Imran Shahid, Qaiser Jabeen

• Publisher: Bentham Science Publishers
• Year: 2008
• Print ISBN:
  9789815123456
• eBook ISBN:
  9789815123432
• Topic: Medicina
• Subtopic: Gastroenterologia ed epatologia

The burden of hepatitis C virus (HCV) infection on the public health care system continues to remain significant despite the remarkable progress made in HCV therapeutics in the recent past. There are now almost a dozen oral interferon-free direct-acting antivirals available for the treatment of hepatitis C virus infection. Despite advances in the treatment of HCV, therapeutic gaps remain that are yet to be fully explored. Researchers and scientists still strive to understand virus-host interactions to map the disease's progression along with extrahepatic manifestations and virus invasion strategies impacting the host's immune system. This book briefly discusses the biology of HCV infection, virus-host interactions, molecular epidemiology of the infection, and the full spectrum of immune responses to hepatitis C. It also provides in-depth information about HCV, clinical diagnostics, and therapeutic knowledge to all stakeholders involved in HCV screening, diagnosis, treatment, and management. Topics covered in the chapters include 1) HCV-host interactions leading to asymptomatic acute infection, 2) the progression of acute HCV infection to chronic disease and subsequent extrahepatic comorbidities, 3) Innate and adaptive immune responses in HCV infections, 4) Consensus-based Approaches for Hepatitis C Screening and Diagnosis, 5) advances in hepatitis C therapy and global management of HCV, and 6) the outcomes of Oral Interferon-free Direct-acting Antivirals as Combination Therapies to Cure Hepatitis C. This book is a valuable addition to undergraduate and postgraduate hepatology students and physicians, clinicians, hepatologists, and health care officials involved in HCV clinical diagnosis and therapeutics.

Table of contents

• Welcome
• Table of Content
• Title
• BENTHAM SCIENCE PUBLISHERS LTD.
• FOREWORD
• PREFACE
• DEDICATION
• HCV-Host Interactions: A Plethora of Genes and their Intricate Interplay Part 1: Virus Specific Factors
• HCV-Host Interactions: Interplay Part 2: Host Related Determinants and Intracellular Signaling
• Immune Responses and Immunopathology of Acute and Chronic Hepatitis C Virus Infection
• Consensus-based Approaches for Hepatitis C Screening and Diagnosis in General and Vulnerable Populations
• The Current Paradigms of Hepatitis C Diagnosis and Innovations in the Pipeline
• Current Landscape of HCV Therapeutics
• Consensus Treatment Guidelines and Recommendations to Treat Hepatitis-C Infected Populations
• Treatment Recommendations for Harder-to-Cure and Vulnerable Populations
• Real-World Therapeutic Outcomes of Direct-Acting Antiviral Regimens and Formidable Challenges
• Appling Drug Discovery in HCV-therapeutics: A snapshot from the past and glimpse into the future
• Global Health Sector Strategy (2016-2021) Toward Ending Hepatitis-C: Promises, Policies, and Progress
• WHO Hepatitis C Elimination Goal by 2030: Feasible or not?
• APPENDICES