The Chemistry and Biology of Beta-Lactams

Zerong Wang

• Publisher: Apple Academic Press
• Year: 2023
• eBook ISBN: 9781000755213
• Edition: 1
• Topic: Biological Sciences
• Subtopic: Biochemistry in Medicine
• Index: Biological Sciences

This new volume provides the most updated information about beta-lactams relating to both the pharmaceutical industry and synthetic chemistry. It provides the antibiotic activities as well as chemical reactivities of beta-lactams, which are important because they are commonly applied as antibiotics in the treatment of bacterial infections. The volume provides comprehensive coverage of most of the known beta-lactam antibiotics with both structural and biological information, antibiotic mechanisms, self-defense mechanisms of bacteria, nearly all known synthetic methods for the preparation of beta-lactams, and possible reactions in which beta-lactams can participate.

Key features:

• Provides the most comprehensive collection of beta-lactam antibiotics (up to 269 molecules) with chemical structures, CAS number, IUPAC names and associated biological activities attached
• Offers a comprehensive and detailed collection of beta-lactamase databases
• Explains the self-defense mechanisms of bacteria for surviving, including the formation of biofilm and conversion into L-form and secretion of beta-lactamase to deactivate the beta-lactam antibiotics
• Provides a comprehensive survey on the synthetic methods to make beta-lactams
• Gives all of the possible reactions involving beta-lactams as the starting materials
• Surveys over 1000 research works and includes all available DOI information

The volume is a valuable resource on the antibiotic activities as well as chemical reactivities of beta-lactams for researchers and scientists, faculty, and advanced students, as well as for industry professionals working in medicinal and pharmaceutical chemistry, organic chemistry, organic synthesis, heterocycles, proteins and peptides.

Table of contents

• Cover Page
• Half Title page
• Title Page
• Copyright Page
• About the Author
• Contents
• Abbreviations
• Acknowledgments
• Preface
• 1 β-Lactams and Antibiotics
• 2 Antimicrobial Activity of β-Lactams and Bacterial Resistance
• 3 Synthetic Methods of β-Lactams
• 4 Reactions of β-Lactams
• Index