Protein Interactions
The Molecular Basis of Interactomics
- English
- ePUB (mobile friendly)
- Available on iOS & Android
About this book
A fundamental guide to the burgeoning field of protein interactions
From enzymes to transcription factors to cell membrane receptors, proteins are at the heart of biological cell function. Virtually all cellular processes are governed by their interactions, with one another, with cell bodies, with DNA, or with small molecules. The systematic study of these interactions is called Interactomics, and research within this new field promises to shape the future of molecular cell biology.
Protein Interactions goes beyond any existing guide to protein interactions, presenting the first truly comprehensive overview of the field. Edited by two leading scholars in the field of protein bioinformatics, this book covers all known categories of protein interaction, stable as well as transient, as well as the effect of mutations and post-translational modifications on the interaction behavior.
Protein Interactions readers will also find:
- Introductory chapters on protein structure, conformational dynamics, and protein-protein binding interfaces
- A data-driven approach incorporating machine learning and integrating experimental data into computational models
- An outlook on the current challenges in the field and suggestions for future research
Protein Interactions will serve as a fundamental resource for novice researchers who want a systematic introduction to interactomics, as well as for experienced cell biologists and bioinformaticians who want to gain an edge in this exciting new field.
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Information
Table of contents
- Cover
- Table of Contents
- Title Page
- Copyright
- Preface
- 1 Protein Structure and Conformational Dynamics
- 2 Protein-Protein-Binding Interfaces
- 3 Correlated Coevolving Mutations at Protein-Protein Interfaces
- 4 Computational Protein-Protein Docking
- 5 Identification of Putative Protein Complexes in Protein-Protein Interaction Networks
- 6 Structure, Composition, and Modeling of Protein Complexes
- 7 Live-Cell Structural Biology to Solve Molecular Mechanisms: Structural Dynamics in the Exocyst Function
- 8 Kinetics and Thermodynamics of Protein-Protein Encounter
- 9 Markov State Models of Protein-Protein Encounters
- 10 Transcription Factor - DNA Complexes
- 11 The Chromatin Interaction System
- 12 RNA-Protein Interactomics
- 13 Interaction Between Proteins and Biological Membranes
- 14 Interactions of Proteins with Small Molecules, Allosteric Effects
- 15 Effects of Mutations in Proteins on Their Interactions
- 16 Not Quite the Same: How Alternative Splicing Affects Protein Interactions
- 17 Phosphorylation-Based Molecular Switches
- 18 Summary and Outlook
- Index
- End User License Agreement