Multicomponent Reactions towards Heterocycles
Concepts and Applications
- English
- ePUB (mobile friendly)
- Available on iOS & Android
Multicomponent Reactions towards Heterocycles
Concepts and Applications
About this book
Presents a wide-ranging overview of essential topics and recent advances in MCR chemistry
Heterocycles are a central component in natural product chemistry, pharmaceuticals, agrochemicals, and material science. New synthetic methodologies integrating the sequencing of multicomponent reactions (MCRs) are today being used for the rapid synthesis of diversified heterocycles in just one step. Multicomponent Reactions towards Heterocycles presents an up-to-date summary MCR chemistry with a focus on the conjugation between modern synthetic methodologies and MCRs.
Featuring contributions by leaders in the field, this comprehensive resource highlights applications of MCRs in natural products and intermediate synthesis, discusses current trends and future prospects in MCR chemistry, outlines novel multicomponent procedures, and more. The authors provide the practical information required for designing new reaction strategies and mechanisms, covering topics including MCR-based green synthetic methods, cyclization and cycloaddition reactions, heterocycle multicomponent syntheses in a continuous flow, catalytic alkynoyl generation, MCR synthesis of saturated heterocycles, and C–H functionalization and multicomponent reactions.
- Provides a thorough overview of heterocycles as input in multicomponent reactions
- Discusses recent advances in the field of MCR chemistry and progress in the synthesis and functionalization of heterocycles
- Demonstrates the use of MCRs to simplify synthetic design and achieve complexity and diversity in novel bioactive molecules
- Highlights examples of multicomponent polymerizations, target-oriented synthesis, and applications of MCR in medicinal chemistry
- Explains the methodology of using on-resin MCRs to produce heterocycle compounds
Illustrating the key role of MCRs towards heterocycles in natural product synthesis, drug discovery, organic synthesis, and other applications, Multicomponent Reactions towards Heterocycles is required reading for synthetic chemists in academia and industry alike.
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Table of contents
- Cover
- Table of Contents
- Multicomponent Reactions towards Heterocycles
- Copyright
- Preface
- 1 Heterocycles as Inputs in MCRs: An Update
- 2 Heterocycles and Multicomponent Polymerizations
- 3 Multicomponent Reactions in Medicinal Chemistry
- 4 Solid-Phase Heterocycle Synthesis Using Multicomponent Reactions
- 5 Green Synthesis of Heterocycles Via MCRs
- 6 The Use of Flow Chemistry in the Multicomponent Synthesis of Heterocycles
- 7 C–H Functionalization as an Imperative Tool Toward Multicomponent Synthesis and Modification of Heterocycles
- 8 Multicomponent-Switched Reactions in Synthesis of Heterocycles
- 9 Recent Applications of Multicomponent Reactions Toward Heterocyclic Drug Discovery
- 10 Multicomponent Syntheses of Heterocycles by Catalytic Generation of Alkynoyl Intermediates
- 11 Synthesis of Saturated Heterocycles via Multicomponent Reactions
- 12 Multicomponent Reactions and Asymmetric Catalysis
- 13 Recent Trends in Metal-catalyzed MCRs Toward Heterocycles
- Index
- End User License Agreement