Cardiovascular Toxicity and Therapeutic Modalities Targeting Cardio-oncology

From Basic Research to Advanced Study

Imteyaz Qamar, Pawan Kumar Maurya

• Publisher: Academic Press
• Year: 2022
• Print ISBN:
  9780323904612
• eBook ISBN:
  9780323904629
• Topic: Scienze biologiche
• Subtopic: Biologia

Cardiovascular Toxicity and Therapeutic Modalities Targeting Cardio-Oncology: From Basic Research to Advanced Study analyzes the emerging the field of cardio-oncology, reviewing recent advancements in the field, discussing how to monitor and treat cancer survivors for cardiotoxicity, and identifying potential cardiac side effects in novel cancer therapies. By adopting a translational approach, the book first comprehensively covers the basic science, mechanisms and concepts, which is followed by advanced state-of-art of cardio-oncology. Other sections cover tyrosine kinase inhibitors, Anthracyclines, and biomarkers in cardiotoxicity induced by chemotherapeutic drugs, noninvasive cardiovascular imaging techniques, radiotherapy induced cardiovascular, and more. Anti-cancer treatment is associated with serious cardiovascular adverse events, including arterial and pulmonary hypertension, supraventricular and ventricular arrhythmias, systolic and diastolic cardiac dysfunction and coronary artery disease. Progress in cancer therapy over the past decades improved long-term survival but increased cancer therapy-related cardiotoxicity. Both traditional chemotherapeutic agents and newer therapies have demonstrated profound cardiovascular toxicities. It is important to understand the mechanisms of these toxicities to establish strategies for the prevention and management of complications—arrhythmias, heart failure, and even death. - Adopts a translational approach and comprehensively covers the basic science, mechanisms and concepts of cardio-oncology - Outlines the current knowledge of biomarkers in cancer therapy-related cardiotoxicity - Provides an understanding of the mechanisms of cardiovascular toxicity of various therapies that may lead to the identification of novel targets to reduce vascular complications

Table of contents

• Cover
• Front Matter
• Table of Contents
• Copyright
• Contributors
• Preface
• List of Illustrations
• List of Tables
• Chapter 1 : Overview of changes in the cardiovascular system
• Chapter 2 : Cardiovascular disease in cancer survivors: Risk and management
• Chapter 3 : Recent trends in cancer immunotherapy: Pathways and inhibitors
• Chapter 4 : Stroke risk assessment and atrial fibrillation (AF) in cancer patients
• Chapter 5 : Biochemistry of biomarkers in cardiotoxicity induced in chemotherapeutic drugs
• Chapter 6 : Cardiotoxic effects of tyrosine kinase inhibitors directed against VEGFR
• Chapter 7 : Critical insights into cardiotoxicity of anthracyclines
• Chapter 8 : Noninvasive cardiovascular imaging techniques
• Chapter 9 : Cardiovascular risk induced by radiotherapy
• Chapter 10 : Cardiovascular complication from cancer therapy
• Chapter 11 : Novel anticancer drugs related to cardiotoxicity
• Chapter 12 : Principles of cardiovascular rehabilitation
• Chapter 13 : Hematopoietic stem cell transplantation: Sources of cells, cryopreservation, and applications
• Index
• A