Biology of Mycobacterial Lipids

Zeeshan Fatima, Stéphane Canaan

• Publisher: Academic Press
• Year: 2022
• Print ISBN:
  9780323919487
• eBook ISBN:
  9780323919449
• Topic: Ciencias biológicas
• Subtopic: Microbiología

Biology of Mycobacterial Lipids covers various topics pertaining to the advancements and current research in the field of mycobacterial lipids, and on the significant progress in lipidomics, in recent times. The chapters present comprehensive, yet systematic cutting-edge research, comprising mycobacterial lipid terminologies, classifications, biosynthetic pathways, tools and techniques, and functional burgeoning. This unique reference book has contributions from pioneer researchers, experts, and eminent veterans from around the globe. It covers ground-breaking work that will bridge the gap between understanding biochemical patterns related to virulence, pathogenesis, and resistance and elucidating new targets for drug design, identifying biomarkers for predicting risk, early diagnosis, and therapeutic outcome. - Covers major biochemical aspects of mycobacterial lipids, nomenclature, structure and classification, and metabolic pathways - Focuses on recent trends and state-of-the-art technology, used in mycobacterial lipids study - Brings together the functional aspects of mycobacterial lipidome, involvement of lipids in cellular network and signaling, its involvement in virulence and resistance, and host factor manipulations - Highlights the discovery of lipid biomarkers, for diagnostic and therapeutic interventions, using mycobacterial lipidomic studies - Presents lipids at the interface of various other biomolecules with integrative omics aspects

Table of contents

• Cover
• Front Matter
• Table of Contents
• Copyright
• Tribute for Professor David E. Minnikin, MA, DPhil, DSc (1939–2021)
• List of contributors
• Foreword
• Preface
• List of Illustrations
• List of Tables
• Chapter 1 : An overview of mycolic acids: structure–function–classification, biosynthesis, and beyond
• Chapter 2 : Lipid biosynthetic pathways as potential drug targets for emerging mycobacterial pathogens
• Chapter 3 : Mycobacterial lipids in the host–pathogen interface: roles in pathogenesis and host immune response
• Chapter 4 : Lipids and glycolipids as biomarkers of mycobacterial infections
• Chapter 5 : Multifaceted roles of mycobacterium cell envelope glycolipids during host cell membrane interactions
• Chapter 6 : Conserved mechanisms drive host-lipid access, import, and utilization in Mycobacterium tuberculosis and M. marinum
• Chapter 7 : Biological implications of mycobacterial lipids on NKT-cells stimulation
• Chapter 8 : The effect of chemically synthetic mycobacterial mycolates on phospholipidome immunomodulation of murine macrophages
• Chapter 9 : Polyketide synthases in mycobacterial lipid metabolism
• Chapter 10 : Understanding mycobacterial lipid metabolism and employing it as a tool to produce attenuated TB vaccine candidates
• Chapter 11 : Deciphering the physiological role of serine enzymes involved in mycobacterial lipid metabolism using activity-based protein profiling
• Chapter 12 : Intrabacterial lipid inclusions: overview of an amazing organelle
• Chapter 13 : Multiple facets and functions of the toxin mycolactone produced by Mycobacterium ulcerans
• Index
• A