Molecular Nutrition and Mitochondria

Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals

Sergej M. Ostojic

• Publisher: Academic Press
• Year: 2022
• Print ISBN: 9780323902564
• eBook ISBN: 9780323984522
• Topic: Biological Sciences
• Subtopic: Molecular Biology
• Index: Biological Sciences

Molecular Nutrition and Mitochondria: Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals provides a comprehensive examination of molecular aspects of mitochondrial nutrition and how dietary compounds might impact the treatment of mitochondrial dysfunction. Beginning with an overview of the fundamentals of mitochondria physiology and the methods used to evaluate mitochondrial imbalance in clinical practice, the book goes on to outline nutritional shortfalls in mitochondrial dysfunction and highlights the complex intra-organelle milieu affecting interactions between food compounds and mitochondrial co-factors, metabolites, and signaling molecules. Further sections explore the impact of essential nutrients, such as vitamin E, fatty acids, and complex lipids, on mitochondrial biogenesis, as well as non-essential bioactive compounds originating from food that can be evaluated for their mitochondria-modulating potential, such as mitochondria-targeted small molecule antioxidants, plant-based pigments and organic compounds, nucleotides, non-proteogenic amino acids and derivatives, and mitochondria-specific enzyme mimetics from food. Molecular Nutrition and Mitochondria covers the key impacts of nutrition on mitochondria, and is the ideal reference for researchers, students and clinicians looking to develop an in-depth understanding of how dietary compounds can prevent and treat disorders associated with mitochondrial dysfunction. - Describes the fundamentals of mitochondria physiology and considers the methods used to evaluate mitochondrial imbalance in clinical practice - Provides broad biochemical and metabolic background on nutritional deficits found in mitochondrial dysfunction - Explores the prevention and treatment of various inherited and acquired disorders associated with mitochondrial dysfunction - Discusses the link between the dosage for each nutrient (nutritional vs. pharmacological) and the clinical effect - Features a dedicated section on whole-diet interventions and mitochondrial function

Table of contents

• Molecular Nutrition and Mitochondria
• Chapter 1 Targeting mitochondrial dysfunction with nutrients: challenges and opportunities
• Chapter 2 Mitochondrion at the crossroads between nutrients and the epigenome
• Chapter 3 Nutritional assessment and malnutrition in adult patients with mitochondrial disease
• Chapter 4 Therapeutic potential and metabolic impact of alternative respiratory chain enzymes
• Chapter 5 Aging, mitochondrial dysfunctions, and vitamin E
• Chapter 6 The role of B vitamins in protecting mitochondrial function
• Chapter 7 Analysis of the mitochondrial status of murine neuronal N2a cells treated with resveratrol and synthetic isomeric resveratrol analogs: aza-stilbenes
• Chapter 8 Dietary eicosapentaenoic acid and docosahexaenoic acid for mitochondrial biogenesis and dynamics
• Chapter 9 Vitamin C and mitochondrial function in health and exercise
• Chapter 10 Roles of dietary fiber and gut microbial metabolites short-chain fatty acids in regulating mitochondrial function in central nervous system
• Chapter 11 Mitochondria-targeted antioxidants: coenzyme Q10, mito-Q and beyond
• Chapter 12 Flavonoids, mitochondrial enzymes and heart protection
• Chapter 13 Tea polyphenols stimulate mt bioenergetics in cardiometabolic diseases
• Chapter 14 A review of quercetin delivery through nanovectors: cellular and mitochondrial effects on noncommunicable diseases
• Chapter 15 Creatine monohydrate for mitochondrial nutrition
• Chapter 16 Arginine and neuroprotection: a focus on stroke
• Chapter 17 Nutraceuticals for targeting NAD+ to restore mitochondrial function
• Chapter 18 Curcumin for protecting mitochondria and downregulating inflammation
• Chapter 19 Dihydrogen as an innovative nutraceutical for mitochondrial viability
• Chapter 20 Fucoxantin and mitochondrial uncoupling protein 1 in obesity
• Chapter 21 Rice bran extract for the prevention of mitochondrial dysfunction
• Chapter 22 Silymarin as a vitagene modulator: effects on mitochondria integrity in stress conditions
• Chapter 23 Buckwheat trypsin inhibitors: novel nutraceuticals for mitochondrial homeostasis
• Chapter 24 Diet restriction-induced mitochondrial signaling and healthy aging
• Chapter 25 Rejuvenation of mitochondrial function by time-controlled fasting
• Chapter 26 Dietary modulation and mitochondrial DNA damage
• Index