System Vaccinology

The History, the Translational Challenges and the Future

Vijay Kumar Prajapati

• Publisher: Academic Press
• Year: 2022
• Print ISBN:
  9780323859417
• eBook ISBN:
  9780323897860
• Topic: Medicine
• Subtopic: Immunology

Emergence of new and deadly infectious diseases is significantly deteriorating the human health. Development of vaccine by the scientist has become an important weapon to control the spread of infectious diseases as well as to improve the life expectancy at global level in 20th-21st Century. This book will provide the in-depth knowledge of vaccine history, and development of new strategies to design efficacious and safe vaccine molecule. This book will cover the development of system vaccinology and their applications revolutionize the vaccine discovery. This will provide a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials. My purpose to write this book to educate the students and researchers with modern development in the field of vaccinology and empowering the researcher with new tools and methodology for developing potential and immunogenic vaccines. This book will be helpful to solve the curiosity of science and medical background students related with vaccinology and will be helpful to devise a new vaccine molecule to control the spread of new and emerging pathogens. Systems biology is a rapidly expanding research discipline aiming to integrate multifaceted datasets generated using state-of-the-art high- throughput technologies such as arrays and next-generation sequencing. Combined with sophisticated computational analysis we are able to interrogate host responses to infections and vaccination on a systems level, thus generating important new hypotheses and discovering unknown associations between immunological parameters. - Provides in-depth knowledge of vaccine history - Covers the development of system vaccinology and their applications revolutionize the vaccine discovery - Gives insights to the development of new strategies to design efficacious and safe vaccine molecule - Provides a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials - Highlights the importance of differential miRNA expression, microbiome after vaccination for human health - Serves the need of students and researcher for applying computational tools and quick designing of potential molecule which may be proposed for vaccine trial - Take the decisions to perform the kind of experiments for assessment of vaccine immunogenicity - Aims to understand disease pathogenesis and host responses to infection and vaccination - Offers a seamless continuum of scientific discovery and vaccine invention

Table of contents

• Title of Book
• Cover image
• Title page
• Table of Contents
• Copyright
• Table of Contents
• Contributors
• Chapter 1 History of vaccine: from centuries to present
• Chapter 2 Evolution and development of vaccines against major human infections
• Chapter 3 Vaccine Omics: role of bioinformatics in vaccinology
• Chapter 4 Vaccine engineering & structural vaccinology
• Chapter 5 Infection, immunity, and vaccine development
• Chapter 6 Immune responses to vaccines: from classical to systems approaches
• Chapter 7 Leptin: an immunological adjuvant to improve vaccine response in infectious diseases
• Chapter 8 Polymer-based adjuvant requirements for vaccines
• Chapter 9 Circadian rhythmicity and vaccination
• Chapter 10 Controlled human infection modeling and vaccine development
• Chapter 11 Preclinical testing of vaccine candidates in animal models
• Chapter 12 Vaccine human clinical trial
• Chapter 13 Systems vaccinology for the design of rational vaccines against protozoan parasites
• Chapter 14 Cancer vaccine’s multiverse and the future ahead
• Chapter 15 Emerging trends in vaccine delivery systems
• Chapter 16 Vaccine regulation and ethics
• Chapter 17 Future of system vaccinology
• Index