Peptide and Peptidomimetic Therapeutics

From Bench to Bedside

Nir Qvit, Samuel J.S. Rubin

• Publisher: Academic Press
• Year: 2022
• Print ISBN:
  9780128201411
• eBook ISBN:
  9780128204474
• Topic: Biological Sciences
• Subtopic: Biochemistry
• Index: Biological Sciences

Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis. Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics. - Helps researchers and clinicians harness the full of power of peptides and peptidomimetics in their daily work and drug discovery - Features chapters running from "bench to bedside, providing a thorough grounding in fundamental peptide science, drug delivery methods, and targeting of specific disease types - Features chapter contributions from international leaders in peptide science and drug development

Table of contents

• Cover
• Title page
• Table of Contents
• Copyright
• Contents
• List of contributors
• Preface
• List of Illustrations
• List of Tables
• Chapter 1 : Therapeutic peptides: historical perspectives and current development trends
• Chapter 2 : Therapeutic peptidomimetics: targeting the undruggable space
• Chapter 3 : Tailoring peptides and peptidomimetics for targeting protein–protein interactions
• Chapter 4 : Advances in peptide synthesis
• Chapter 5 : Stapled peptidomimetic therapeutics
• Chapter 6 : Ring-closing metathesis/transannular cyclization to azabicyclo[X.Y.0]alkanone dipeptide turn mimics for biomedical applications
• Chapter 7 : The current state of backbone cyclic peptidomimetics and their application to drug discovery*
• Chapter 8 : Pharmacokinetics and pharmacodynamics of peptidomimetics
• Chapter 9 : Formulation of peptides and peptidomimetics
• Chapter 10 : Medical use of cell-penetrating peptides: how far have they come?
• Chapter 11 : Intracellular peptides as drug prototypes
• Chapter 12 : Applications of computational three-dimensional structure prediction for antimicrobial peptides
• Chapter 13 : Knottin peptidomimetics as therapeutics
• Chapter 14 : Venom peptides and peptidomimetics as therapeutics
• Chapter 15 : Therapeutic peptides targeting protein kinase: progress, challenges, and future directions, featuring cancer and cardiovascular disease
• Chapter 16 : Therapeutic peptidomimetics for infectious diseases
• Chapter 17 : Antiparasitic therapeutic peptidomimetics
• Chapter 18 : Peptides and antibiotic resistance
• Chapter 19 : Antimicrobial peptides and the skin and gut microbiomes
• Chapter 20 : Peptide and peptidomimetic-based vaccines
• Chapter 21 : Therapeutic peptidomimetics for cancer treatment
• Chapter 22 : Immunomodulatory peptidomimetics for multiple sclerosis therapy—the story of glatiramer acetate (Copaxone)
• Chapter 23 : Therapeutic peptidomimetics in metabolic diseases
• Chapter 24 : Peptide therapeutics in anesthesiology
• Chapter 25 : Cardiovascular-derived therapeutic peptidomimetics in cardiovascular disease
• Chapter 26 : Noncardiovascular-derived therapeutic peptidomimetics in cardiovascular disease
• Chapter 27 : Clinical and preclinical data on therapeutic peptides
• Chapter 28 : Therapeutic peptides: market and manufacturing
• Chapter 29 : Future perspectives on peptide therapeutics
• Index
• A