Hematology

101 Morphology Updates

Barbara J. Bain

• Publisher: Wiley-Blackwell
• Year: 2023
• Print ISBN:
  9781394179817
• eBook ISBN:
  9781394179770
• Edition: 1
• Topic: Medicine
• Subtopic: Hematology

Hematology

Timely morphology resource based on ongoing series of morphology updates published in the American Journal of Hematology since 2008

This is the first book of its kind, written by renowned author Professor Barbara J. Bain, featuring a collection of instructive cases with interesting morphological features initially published in the American Journal of Hematology. This new book aims to bring these interesting and instructive cases to a wider readership. This book features updated cases and a "Test Yourself" section to aid in reader comprehension and information retention.

Cases covered in Hematology: 101 Morphology Updates include:

• The significance of irregularly contracted cells and hemighosts in sickle cell disease, and striking dyserythropoiesis in sickle cell anemia following an aplastic crisis
• Prominent Howell-Jolly bodies when megaloblastic anemia develops in a hyposplenic patient, and unusual aspects of G6PD deficiency
• The cause of sudden anemia revealed by the blood film, chorea-acanthocytosis and dysplastic neutrophils in an HIV-positive woman
• Neutrophil dysplasia induced by granulocyte colony-stimulating factor, and diagnosis of pyrimidine 5'-nucleotidase deficiency suspected from a blood film

Hematology: 101 Morphology Updates is a key resource for consultant hematologists and clinical scientists, trainee hematologists and biomedical scientists. The audience may use this book to solve difficult diagnostic problems or as a source of teaching cases: for both personal learning, including exam revision or solving difficult cases, and as a teaching resource.

Table of contents

• Cover
• Table of Contents
• Title Page
• Copyright Page
• Preface
• Note to the reader
• Acknowledgements
• Abbreviations
• 1 Malaria – one swallow makes a summer
• 2 The significance of irregularly contracted cells and hemighosts in sickle cell disease
• 3 Striking dyserythropoiesis in sickle cell anemia following an aplastic crisis
• 4 A normal mean cell volume does not exclude a diagnosis of megaloblastic anemia
• 5 Prominent Howell–Jolly bodies when megaloblastic anemia develops in a hyposplenic patient
• 6 A ghostly presence – G6PD deficiency
• 7 G6PD deficiency in patients identified as female
• 8 The cause of sudden anemia revealed by the blood film
• 9 Choreo‐acanthocytosis
• 10 Lead poisoning
• 11 Dysplastic neutrophils in an HIV‐positive woman
• 12 Help with HELLP
• 13 Neutrophil dysplasia induced by granulocyte colony‐stimulating factor
• 14 COVID‐19 and acute kidney injury
• 15 Diagnosis of pyrimidine 5′ nucleotidase deficiency suspected from a blood film
• 16 Bone marrow aspirate in Chédiak–Higashi syndrome
• 17 Phytosterolemia
• 18 Pseudo‐Chédiak–Higashi inclusions together with Auer rods in acute myeloid leukemia
• 19 Botryoid nuclei resulting from cocaine abuse
• 20 Infantile pyknocytosis
• 21 Splenic rupture in cytomegalovirus infection
• 22 A new diagnosis of monoclonal B‐cell lymphocytosis with cytoplasmic inclusions in a patient with COVID‐19
• 23 Pseudoplatelets and apoptosis in Burkitt lymphoma
• 24 What is a promonocyte?
• 25 Persistent neonatal jaundice resulting from hereditary pyropoikilocytosis
• 26 Auer rods or McCrae rods?
• 27 Observation of Auer rods in crushed cells in acute promyelocytic leukemia
• 28 Alpha chain inclusions in peripheral blood erythroblasts and erythrocytes
• 29 Dyserythropoiesis in visceral leishmaniasis
• 30 Compound heterozygosity for hemoglobins S and D
• 31 Granular B lymphoblastic leukemia
• 32 Hyposplenism in adult T‐cell leukemia/lymphoma
• 33 Voxelotor in sickle cell disease
• 34 The importance of a negative image
• 35 Seeing what isn’t there
• 36 A young woman with sudden onset of a severe coagulation abnormality
• 37 Immature Plasmodium falciparum gametocytes in bone marrow
• 38 Acute myeloid leukemia with myelodysplasia‐related changes showing basophilic differentiation
• 39 Thiamine‐responsive megaloblastic anemia in an Iraqi girl
• 40 Teardrop poikilocytes in metastatic carcinoma of the breast
• 41 A blood film that could have averted a splenectomy
• 42 Russell bodies and Mott cells
• 43 Dutcher bodies
• 44 Acute myeloid leukemia with inv(16)(p13.1q22)
• 45 Dysplastic macropolycytes in myelodysplasia‐related acute myeloid leukemia
• 46 Diagnosis of cystinosis from a bone marrow aspirate
• 47 Emperipolesis in a patient receiving romiplostim
• 48 Mechanical hemolysis: a low mean cell volume does not always represent microcytosis
• 49 Transplant‐associated thrombotic microangiopathy
• 50 Neuroblastoma in the bone marrow
• 51 Gray platelet syndrome
• 52 Diagnosis of systemic lupus erythematosus from a bone marrow aspirate
• 53 Diagnosis from a blood film following a dog bite
• 54 Interpreting a postpartum Kleihauer test
• 55 Dengue fever in returning travellers
• 56 Auer rod‐like inclusions in multiple myeloma
• 57 Azurophilic granules in myeloma cells
• 58 Plasmodium knowlesi
• 59 The cytological features of NPM1‐mutated acute myeloid leukemia
• 60 Irregularly contracted cells in Wilson disease
• 61 Pseudo‐Pelger–Huët neutrophil morphology due to sodium valproate toxicity
• 62 The distinctive cytological features of T‐cell prolymphocytic leukemia
• 63 Eosinophil morphology in the reactive eosinophilia of Hodgkin lymphoma
• 64 Malaria pigment
• 65 Salmonella colonies in a bone marrow film
• 66 Severe babesiosis due to Babesia divergens acquired in the UK
• 67 Congenital acute megakaryoblastic leukemia
• 68 Basophilic differentiation in transient abnormal myelopoiesis
• 69 Methylene blue‐induced Heinz body hemolytic anemia in a premature neonate
• 70 Neutrophil vacuolation in acetominophen‐induced acute liver failure
• 71 Howell–Jolly bodies in acute hemolytic anemia
• 72 The distinctive micromegakaryocytes of transformed chronic myeloid leukemia
• 73 Copper deficiency
• 74 Chronic neutrophilic leukemia
• 75 Neutrophilic leukemoid reaction in multiple myeloma
• 76 Persistent polyclonal B lymphocytosis
• 77 Non‐hemopoietic cells in the blood and bone marrow
• 78 It’s a black day – metastatic melanoma in the bone marrow
• 79 Dehydrated hereditary stomatocytosis
• 80 Circulating lymphoma cells in intravascular large B‐cell lymphoma
• 81 Unusual inclusions in hemoglobin H disease post‐splenectomy
• 82 An unexpectedly bizarre blood film in hemoglobin H disease
• 83 Acute myeloid leukemia with a severe coagulopathy and t(8;16)(p11;p13)
• 84 Cold autoimmune hemolytic anemia secondary to atypical pneumonia
• 85 A confusing ‘white cell count’ – circulating micromegakaryocytes in post‐thrombocythemia myelofibrosis
• 86 Diagnosis of follicular lymphoma from the peripheral blood
• 87 Transformation of follicular lymphoma
• 88 Cytology of systemic mastocytosis
• 89 Systemic mastocytosis – the importance of looking within bone marrow fragments
• 90 Schistocytosis is not always microangiopathic hemolytic anemia
• 91 Hemoglobin C disease
• 92 Hemoglobin St Mary’s
• 93 Congenital sideroblastic anemia in a female
• 94 A puzzling case of methemoglobinemia
• 95 Hodgkin lymphoma in a bone marrow aspirate
• 96 Giant proerythroblasts in pure red cell aplasia due to parvovirus B19 infection in a patient with rheumatoid arthritis
• 97 A myeloid neoplasm with FIP1L1::PDGFRA presenting as acute myeloid leukemia
• 98 Breast implant‐associated anaplastic large cell lymphoma
• 99 Large granular lymphocytosis induced by dasatinib
• 100 The distinctive cytology and disease evolution of blastic plasmacytoid dendritic cell neoplasm
• 101 Platelet phagocytosis as a cause of pseudothrombocytopenia
• Test yourself
• Answers to test cases
• Index
• End User License Agreement