RNA Therapeutics
eBook - ePub

RNA Therapeutics

The Evolving Landscape of RNA Therapeutics

  1. 472 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

RNA Therapeutics

The Evolving Landscape of RNA Therapeutics

About this book

RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies. Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development. - Features leading experts in the field of RNA therapeutics, spanning all classes of RNA therapies - Provides a detailed examination of approved RNA therapies and lessons learned from failed therapeutics - Covers all aspects of therapeutic discovery and preclinical development, as well as clinical translation, manufacturing and regulatory aspects

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Yes, you can access RNA Therapeutics by Paloma H. Giangrande,Vittorio de Franciscis,John J. Rossi in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Biochemistry. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. RNA Therapeutics
  2. Chapter 1 Targeting chromatin: Transcriptional gene activation (saRNA)
  3. Chapter 2 Argonaute and TNRC6, partners in RNAi
  4. Chapter 3 Targeted RNA therapeutics for treatment of cancer and immunomodulation
  5. Chapter 4 Extrahepatic delivery of RNA to immune cells
  6. Chapter 5 Aptamer-based protein inhibitors
  7. Chapter 6 Lessons learned from developing an oligonucleotide drug for a rare disease
  8. Chapter 7 Nucleoside modifications of in vitro transcribed mRNA to reduce immunogenicity and improve translation of prophylactic and therapeutic antigens
  9. Chapter 8 SOMAmer reagents and the SomaScan platform: Chemically modified aptamers and their applications in therapeutics, diagnostics, and proteomics
  10. Chapter 9 CMC and regulatory aspects of oligonucleotide therapeutics☆
  11. Chapter 10 CMC: Regulatory landscape
  12. Chapter 11 CMC and manufacturing
  13. Chapter 12 RNA delivery for cancer gene therapy
  14. Chapter 13 Combinatorial RNA therapies in cancer immunotherapy: Challenges and directions
  15. Index