How We Age
eBook - ePub

How We Age

The Science of Longevity

  1. English
  2. ePUB (mobile friendly)
  3. Available on iOS & Android
eBook - ePub

How We Age

The Science of Longevity

About this book

How recent breakthroughs in longevity research offer clues about human aging

All of us would like to live longer, or to slow the debilitating effects of age. In How We Age, Coleen Murphy shows how recent research on longevity and aging may be bringing us closer to this goal. Murphy, a leading scholar of aging, explains that the study of model systems, particularly simple invertebrate animals, combined with breakthroughs in genomic methods, have allowed scientists to probe the molecular mechanisms of longevity and aging. Understanding the fundamental biological rules that govern aging in model systems provides clues about how we might slow human aging, which could lead in turn to new therapeutics and treatments for age-related disease.

Among other vivid examples, Murphy describes research that shows how changing a single gene in the nematode worm C. elegans doubles its lifespan, extending not only the end of life but also the youthful, healthy part of life. Drawing on work in her own lab as well as other recent research, Murphy chronicles the history and current state of the field, explaining longevity's links to reproduction and mating, sensory and cognitive function, inheritances from our ancestors, and the gut microbiome. Written with clarity and wit, How We Age provides a guide to the science: what we know about aging, how we know what we know, and what we can do with this new knowledge.

Frequently asked questions

Yes, you can cancel anytime from the Subscription tab in your account settings on the Perlego website. Your subscription will stay active until the end of your current billing period. Learn how to cancel your subscription.
At the moment all of our mobile-responsive ePub books are available to download via the app. Most of our PDFs are also available to download and we're working on making the final remaining ones downloadable now. Learn more here.
Perlego offers two plans: Essential and Complete
  • Essential is ideal for learners and professionals who enjoy exploring a wide range of subjects. Access the Essential Library with 800,000+ trusted titles and best-sellers across business, personal growth, and the humanities. Includes unlimited reading time and Standard Read Aloud voice.
  • Complete: Perfect for advanced learners and researchers needing full, unrestricted access. Unlock 1.4M+ books across hundreds of subjects, including academic and specialized titles. The Complete Plan also includes advanced features like Premium Read Aloud and Research Assistant.
Both plans are available with monthly, semester, or annual billing cycles.
We are an online textbook subscription service, where you can get access to an entire online library for less than the price of a single book per month. With over 1 million books across 1000+ topics, weā€™ve got you covered! Learn more here.
Look out for the read-aloud symbol on your next book to see if you can listen to it. The read-aloud tool reads text aloud for you, highlighting the text as it is being read. You can pause it, speed it up and slow it down. Learn more here.
Yes! You can use the Perlego app on both iOS or Android devices to read anytime, anywhere ā€” even offline. Perfect for commutes or when youā€™re on the go.
Please note we cannot support devices running on iOS 13 and Android 7 or earlier. Learn more about using the app.
Yes, you can access How We Age by Coleen T. Murphy in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Biology. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. Cover
  2. Title Page
  3. Copyright
  4. Dedication
  5. Contents
  6. Acknowledgments
  7. List of Abbreviations
  8. Introduction
  9. 1. Ethics and Economics of Longevity: Is It Right to Study Aging?
  10. 2. Why Do We Age?
  11. 3. Studying the Genetics of Human Longevity: Centenarians and What We Can Learn from Them
  12. 4. Long-Lived Species and Longevity Mutants of Model Organisms
  13. 5. What Is Aging (and How Can We Measure It)? Biomarkers of Aging and ā€œQuality of Lifeā€ Metrics
  14. 6. Insulin Signaling, FOXO Targets, and the Regulation of Longevity and Reproduction
  15. 7. Dietary Restriction: Nutrient and Genetic Regulation of Longevity and Reproduction
  16. 8. Taking out the Trash: Molecular Homeostasis in the Regulation of Longevity
  17. 9. Powering Longevity: Mitochondriaā€™s Role in Aging and Longevity
  18. 10. Dracula and Wolverine: How DNA Repair and Cell Replacement Can Help Us Live Long
  19. 11. Use It or Lose It: Reproductive Aging, the Germline, and Longevity
  20. 12. Sex, Flies (and Worms), and Videotape: The Battle of the Sexes
  21. 13. I See Dead Flies: Neurons and Sensory Regulation of Longevity
  22. 14. Donā€™t You Forget about Me: What We Are Learning about Cognitive Aging and How to Slow It
  23. 15. Lamarckā€™s Revenge? Transgenerational Inheritance, the ā€œMolecular Clock,ā€ and the Epigenetic Regulation of Longevity
  24. 16. Gut Feelings: The Microbiome and Aging
  25. 17. Long Life in a Pill? The Future of Longevity: From Bench to Biotech
  26. Notes
  27. Index