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About this book
Understanding mechanisms of gene regulation that are independent of the DNA sequence itself - epigenetics - has the potential to overthrow long-held views on central topics in biology, such as the biology of disease or the evolution of species. High throughput technologies reveal epigenetic mechanisms at a genome-wide level, giving rise to epigenomics as a new discipline with a distinct set of research questions and methods. Leading experts from academia, the biotechnology and pharmaceutical industries explain the role of epigenomics in a wide range of contexts, covering basic chromatin biology, imprinting at a genome-wide level, and epigenomics in disease biology and epidemiology. Details on assays and sequencing technology serve as an up-to-date overview of the available technological tool kit. A reliable guide for newcomers to the field as well as experienced scientists, this is a unique resource for anyone interested in applying the power of twenty-first-century genomics to epigenetic studies.
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Information
Table of contents
- Cover
- Epigenomics From Chromatin Biology to Therapeutics
- Title
- Copyright
- Dedication
- Contents
- Contributors
- Foreword
- Preface
- Part I Basics of chromatin biology and biochemistry
- Part II Epigenomic imprinting and stem cells
- Part III Epigenomic assays and sequencing technology
- Part IV Epigenomics in disease biology
- Part V Epigenomics in neurodegenerative diseases
- Part VI Epigenetic variation, polymorphism, and epidemiological perspectives
- Index