MRI-Negative Epilepsy

Evaluation and Surgical Management

Elson L. So, Philippe Ryvlin

• Publisher: Cambridge University Press
• Year: 2015
• Print ISBN:
  9781107034235
• eBook ISBN:
  9781316190876
• Topic: Medicine
• Subtopic: Neurology

Drug-resistant epilepsy with negative MRI is frequently seen in patients considered for epilepsy surgery; however, clinical evaluation and surgical treatment is very complex and challenging. Advanced imaging techniques are needed to detect the location of the epileptogenic zone. In most cases, intracranial EEG recording is required to delineate the region of seizure onset - this carries some risks of major complications. Moreover, the borders between the recorded seizure onset and the location of important brain functions are often indistinct in MRI-negative epilepsy. Overall, the outcome of MRI-negative surgery is less favorable than that of MRI-positive surgery, but it can significantly improve with optimal management. Each chapter critically appraises the role and value of specific diagnostic and treatment techniques to address the challenges of MRI-negative epilepsy surgery. Authors critique evidence and share their expertise on the diagnostic options and surgical approaches that make epilepsy surgery possible and worthwhile in patients with this condition.

Table of contents

• Cover
• Half-title
• Title page
• Copyright information
• Dedication
• Table of contents
• List of contributors
• Preface
• Chapter 1 Scope and implications of MRI-negative refractory focal epilepsy
• Chapter 2 Seizure semiology and scalp EEG in MRI-negative refractory focal epilepsy
• Chapter 3 Clinical and advanced techniques for optimizing MRI in refractory focal epilepsy
• Chapter 4 PET in MRI-negative refractory focal epilepsy
• Chapter 5 Advanced SPECT image processing in MRI-negative refractory focal epilepsy
• Chapter 6 MEG and magnetic source imaging in MRI-negative refractory focal epilepsy
• Chapter 7 Electric source imaging in MRI-negative refractory focal epilepsy
• Chapter 8 Functional MRI in MRI-negative refractory focal epilepsy
• Chapter 9 Multimodality image coregistration for MRI-negative epilepsy surgery
• Chapter 10 Subdural electrode implantation and recording in MRI-negative epilepsy surgery
• Chapter 11 Depth electrode and stereoelectroencephalography in MRI-negative epilepsy
• Chapter 12 Ultraslow and high-frequency recordings in MRI-negative refractory focal epilepsy
• Chapter 13 Cortical mapping in MRI-negative epilepsy surgery
• Chapter 14 Localization and surgery for MRI-negative temporal lobe and temporal-plus epilepsies
• Chapter 15 Localization and surgery in MRI-negative frontal lobe epilepsies
• Chapter 16 Localization and surgery in MRI-negative posterior cortex epilepsies
• Chapter 17 MRI-negative refractory focal epilepsy in childhood
• Chapter 18 Surgical approaches and techniques in MRI-negative focal epilepsy
• Chapter 19 Histopathology findings in MRI-negative focal epilepsy
• Chapter 20 Neuropsychological issues in MRI-negative focal epilepsy surgery: evaluation and outcomes
• Chapter 21 Conclusion
• Index