- English
- PDF
- Available on iOS & Android
About this book
This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases. The book is packaged with a password, giving the user online access to all the text and images.
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Information
Table of contents
- Cover
- Half title
- Title
- Copyright
- Contents
- List of contributors
- 1 Introduction: classification of neurodegenerative diseases
- 2 Clinical aspects of dementia
- 3 Clinical aspects of movement disorders
- 4 Ethical, health and safety considerations
- 5 Practical approach to diagnosis: sampling and basic stains
- 6 Molecular methods
- 7 Alzheimer’s disease
- 8 Tauopathies
- 9 Synucleinopathies
- 10 Human prion diseases
- 11 Neurodegenerative diseases linked to trinucleotide repeats
- 12 Amyotrophic lateral sclerosis and frontotemporal lobar degeneration
- 13 Other neurodegenerative conditions I: hereditary cerebral amyloid angiopathies
- 14 Other neurodegenerative conditions II: familial encephalopathy with neuroserpin inclusion bodies
- 15 Other neurogenerative conditions III: hereditary ferritinopathies
- 16 Other neurogenerative conditions IV: neurodegeneration with brain iron accumulation
- 17 Concomitant pathologies I: cerebrovascular diseases
- 18 Concomitant pathologies II: neurodegenerative conditions
- Appendix A: Molecular classification of frontotemporal lobar degeneration (FTLD) with genetic correlations
- Appendix B: Scheme for evaluation of frontotemporal lobar degeneration (FTLD)
- Index