- English
- PDF
- Available on iOS & Android
About this book
Whereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.
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Information
Table of contents
- Cover
- Half-Title page
- Series page
- Title page
- Copyright page
- Contents
- List of contributors
- 1 An introduction to systems genetics
- 2 Computational paradigms for analyzing genetic interaction networks
- 3 Mapping genetic interactions across many phenotypes in metazoan cells
- 4 Genetic interactions and network reliability
- 5 Synthetic lethality and chemoresistance in cancer
- 6 Joining the dots: network analysis of gene perturbation data
- 7 High-content screening in infectious diseases: new drugs against bugs
- 8 Inferring genetic architecture from systems genetics studies
- 9 Bayesian inference for model selection: an application to aberrant signallingpathways in chronic myeloid leukaemia
- 10 Dynamic network models of protein complexes
- 11 Phenotype state spaces and strategies for exploring them
- 12 Automated behavioural fingerprinting of Caenorhabditis elegans mutants
- Index