White Matter Dementia

Christopher M. Filley

• Publisher: Cambridge University Press
• Year: 2016
• Print ISBN:
  9781107035416
• eBook ISBN:
  9781316665312
• Topic: Medicine
• Subtopic: Neurology

Breaking away from prevailing views of dementia that rely heavily on the role of the cerebral cortex, the new perspective put forth here highlights white matter-cognition relationships, presenting an expanded view of dementia and its neurobiological origins. Based on detailed patient observations, extensive clinical research and an exhaustive literature review, this book discusses the novel concept of white matter dementia, offering hope for better understanding and treatment of dementing illness. Covering topics such as white matter neurobiology, mild cognitive dysfunction and Alzheimer's disease, the author reconsiders brain-behavior relationships and expands the concept of dementia, discussing implications for diagnosis, treatment (medical, surgical, rehabilitative, and psychiatric) and therapeutic innovations aimed at prevention of white matter damage and restoration of myelin. This unique book is an absolute must-have for all medical specialists and consultants in neurology, neuropsychiatry, and neuropsychology involved with the growing challenge of dementia.

Table of contents

• Cover
• Half-title page
• Title page
• Copyright page
• Dedication
• Contents
• Foreword
• Preface
• Chapter 1 Brain–behavior relationships: a reconsideration
• Chapter 2 The essential contributions of neuroimaging
• Chapter 3 White matter neurobiology
• Chapter 4 A neuroanatomic overview of dementia
• Chapter 5 Expanding the concept of dementia
• Chapter 6 White matter disorders
• Chapter 7 White matter dementia
• Chapter 8 Mild cognitive dysfunction: a precursor syndrome
• Chapter 9 Diagnosis
• Chapter 10 Prognosis
• Chapter 11 Treatment
• Chapter 12 White matter and cognition: research perspectives
• Chapter 13 Therapeutic innovations
• Chapter 14 Alzheimer’s Disease and white matter
• Chapter 15 Chronic traumatic encephalopathy and white matter
• Chapter 16 Beyond corticocentrism
• Index