Treatment Resistant Depression

A Roadmap for Effective Care

John F. Greden, Michelle B. Riba, Melvin G. McInnis, John F. Greden, Michelle B. Riba, Melvin G. McInnis

• Publisher: American Psychiatric Association Publishing
• Year: 2011
• Print ISBN: 9781585624096
• eBook ISBN: 9781585629534
• Topic: Medicine
• Subtopic: Psychiatry & Mental Health

As many as 35-40% of patients afflicted with Major Depressive Disorder (MDD) are treatment resistant, a situation that places a massive emotional and financial burden on society and challenges the mental health profession to develop new treatment paradigms and practices. Even the most astute clinicians can be frustrated when treatment options fail to be effective or work for only a brief time, leaving them to wonder what course to pursue next. Treatment Resistant Depression: A Roadmap for Effective Care gives clinicians and their patients what they need most desperately: a sequence of steps that reflect state-of-the-art diagnostic procedures and integrates all evidence-based treatment modalities -- in short, a roadmap to wellness and recovery.

Based primarily on the experiences of the authors, all of whom are leading researchers and/or clinicians in Treatment Resistant Depression and affiliated with the University of Michigan Comprehensive Depression Center, the book also draws upon the clinical research advances and treatment innovations of programs around the world. Although the book's step-by-step organization is clear and easy to follow, its coverage, scope, and level of sophistication are anything but simplified. This book • Is comprehensive, addressing treatment options, including psychopharmacotherapy, psychotherapy, neuromodulation (ECT, transcranial magnetic stimulation, deep brain stimulation, vagus nerve stimulation), exercise, nutrition, self-management approaches to enhance adherence, behavioral sleep programs, and others• Addresses treatment resistant depression across the lifespan, reflecting the diverse demographics of depression, which knows no age, gender, or socioeconomic status• Emphasizes the authors' commitment to early intervention and provides techniques for identifying young people who are at risk for developing depression or already expressing symptoms of the disease• Recognizes the chronicity of depression, rather than focusing on only the acute stage, and in this way allows for more effective treatment over the patient's lifetime• Introduces self-management as playing a critical role in the patient's prognosis, engagement, adherence to clinical steps that help maintain recovery, and self-esteem• Promotes the development of new, personalized, and predictive biomarkers to target treatment more effectively.

Designed to be useful across disciplines and treatment modalities, the book includes a multitude of tables, graphs, and learning aids that will benefit students, instructors, and clinicians. At the same time, the book promises to be a valuable resource for patients and their families, since Treatment Resistant Depression is both difficult to live with and little understood. No other book offers so much practical guidance, sound research and hope.

Table of contents

• Cover Page
• Title Page
• Copyright Page
• Contents
• Contributors
• Disclosure of Interests
• Foreword
• Preface
• Dedication and Acknowledgements
• Chapter One Treatment Resistant Depression Overview of the University of Michigan Depression Center Roadmap
• Chapter Two Psychopharmacological Roadmap for Treatment Resistant Depression
• Chapter Three Treatment Resistant Depression in Adolescents
• Chapter Four Recognizing and Treating Depression and Bipolar Disorder on College Campuses Early Identification and Intervention
• Chapter Five Treatment Resistant Depression in Pregnant Women
• Chapter Six Treatment Resistant Depression in Later Life
• Chapter Seven Treatment Resistant Depression and Comorbid Medical Problems Cardiovascular Disease and Cancer
• Chapter Eight Alcohol and Drug Use Contributions to Treatment Resistance in Patients With Depression
• Chapter Nine Sleep and Circadian Rhythms An Understudied Area in Treatment Resistant Depression
• Chapter Ten Psychotherapy Strategies for Treatment Resistant Depression
• Chapter Eleven Device-Related Neuromodulation in Treatment Resistant Depression
• Chapter Twelve Exercise, Nutrition, and Treatment Resistant Depression
• Chapter Thirteen The Bipolar Disorder Medical Care Model A Collaborative Approach for Reducing Disparities in Medical Care Among Patients With Bipolar Disorder
• Chapter Fourteen Expanding Services for Patients With Treatment Resistant Depression The Role of Peer Support
• Chapter Fifteen Genetics of Mood Disorders General Principles and Potential Applications for Treatment Resistant Depression
• Index