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Function and Evolution of Repeated DNA Sequences
About this book
The genome of a living being is composed of DNA sequences with diverse origins. Beyond single-copy genes, whose product has a biological function that can be inferred by experimentation, certain DNA sequences, present in a large number of copies, escape the most refined approaches aimed at elucidating their precise role.
The existence of what 20th century geneticists had already perceived (and wrongly described as "junk DNA"!) was confirmed by the sequencing of the first complex genomes, including that of Homo sapiens. A large part of what defines a living thing is not unique, but repeated, sometimes a very large number of times, increasing in complexity with successive duplications and multiplication.
Understanding and defining the many functions of this myriad of repeated sequences, as well as their evolution through natural selection, has become one of the major challenges for 21st century genomics.
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Information
Table of contents
- Cover
- Table of Contents
- Title Page
- Copyright Page
- Foreword
- Introduction: About Repeated Genomes
- 1 Whole-Genome Duplications, a Source of Redundancy at the Entire-Genome Scale
- 2 Segmental Duplications and CNVs: Adaptive Potential of Structural Polymorphism
- 3 Transposable Elements: Parasites that Shape Genome Evolution
- 4 Insights Into the Evolutionary Diversity of Centromeres
- 5 Evolution and Functions of Telomeres
- 6 G-quadruplexes: Structure, Detection and Functions
- 7 Satellite DNA, Microsatellites and Minisatellites
- 8 CRISPR-Cas: An Adaptive Immune System
- List of Authors
- Index
- End User License Agreement