Oral Bioavailability and Drug Delivery

From Basics to Advanced Concepts and Applications

Ming Hu, Xiaoling Li, Ming Hu, Xiaoling Li

• Publisher: Wiley
• Year: 2023
• ISBN:
  9781119660668
• Edition: 1
• Topic: Medizin
• Subtopic: Pharmakologie

ORAL BIOAVAILABILITY AND DRUG DELIVERY

Improve the performance and viability of newly-developed and approved drugs with this crucial guide

Bioavailability is the parameter which measures the rate and extent to which a drug reaches a user's circulatory system depending on the method of administration. For example, intravenous administration produces a bioavailability of 100%, since the drugs are injected directly into the circulatory system; in the case of oral administration, however, bioavailability can vary widely based on factors which, if not properly understood, can result in a failure in drug development, adverse effects, and other complications. The mechanics of oral bioavailability are therefore critical aspects of drug development.

Oral Bioavailability and Drug Delivery provides a comprehensive coverage of this subject as well as its drug development applications. Beginning with basic terminology and fundamental concepts, it provides a thorough understanding of the challenges and barriers to oral bioavailability as well as the possibilities for improving this parameter. The resulting book is an indispensable tool for drug development research.

Oral Bioavailability and Drug Delivery readers will also find:

• Discussion questions in many chapters to facilitate comprehension
• Detailed discussion of topics including dissolution, absorption, metabolism, and more
• Real-world examples of methods in actions throughout

Oral Bioavailability and Drug Delivery is ideal for pharmaceutical and biotechnology scientists working in drug discovery and development; researchers in chemistry, biology, pharmacology, immunology, neuroscience, and other related fields; and graduate courses in drug development and delivery.

Table of contents

• Cover
• Title Page
• Copyright
• Contents
• List of Contributors
• Foreword
• Preface
• Chapter 1 Barriers to Oral Bioavailability – An Overview
• Chapter 2 Solubility of Pharmaceutical Solids
• Chapter 3 In Vitro Dissolution of Pharmaceutical Solids
• Chapter 4 Biological and Physiological Features of the Gastrointestinal Tract Relevant to Oral Drug Absorption
• Chapter 5 Absorption of Drugs Via Passive Diffusion and Carrier‐Mediated Pathways
• Chapter 6 Determinant Factors for Passive Absorption of Drugs
• Chapter 7 Protein Binding and Drug Distribution
• Chapter 8 Drug Transport Across the Placental Barrier
• Chapter 9 Biopharmaceutics Classification System: Theory and Practice
• Chapter 10 Effects of Food on Drug Absorption
• Chapter 11 Drug Metabolism in Gastrointestinal Tract
• Chapter 12 Liver Drug Metabolism
• Chapter 13 Urinary Excretion of Drugs and Drug Reabsorption
• Chapter 14 Excretion of Drugs and Their Metabolites into the Bile
• Chapter 15 Pharmacokinetic Behaviors of Orally Administered Drugs
• Chapter 16 In Vitro‐In Vivo Correlations of Pharmaceutical Dosage Forms
• Chapter 17 Advanced Concepts in Oral Bioavailability Research – An Overview
• Chapter 18 Expression and Pharmaceutical Relevance of Intestinal Transporters
• Chapter 19 Amino Acid Transporters
• Chapter 20 Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide‐Based Pharmaceuticals
• Chapter 21 OATP Transporters in Hepatic and Intestinal Uptake of Orally Administered Drugs
• Chapter 22 ABC Transporters in Intestinal and Liver Efflux
• Chapter 23 Interplay Between Metabolic Enzymes and Transporters
• Chapter 24 Systemic Versus Local Bioavailability Enabled by Recycling
• Chapter 25 Intestinal Microbiome and Its Impact on Metabolism and Safety of Drugs
• Chapter 26 Drug–Drug Interactions and Drug–Dietary Chemical Interactions
• Chapter 27 Regulatory Considerations in Metabolism‐ and Transport‐Based Drug Interactions
• Chapter 28 Formulation Approaches to Improve Oral Bioavailability of Drugs
• Chapter 29 Lipid‐Based and Self‐Emulsifying Oral Drug Delivery Systems
• Chapter 30 Oral Delivery of Nanoparticles: Challenges and Opportunities
• Chapter 31 Oral Delivery of Therapeutic Peptides: Strategies for Product Development
• Chapter 32 Prodrugs to Improve Oral Delivery
• Chapter 33 Gastroretentive Drug Delivery Systems
• Chapter 34 Enhancing Oral Bioavailability Using 3D Printing Technology
• Chapter 35 Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, Monkeys, and Humans
• Chapter 36 In Vivo Methods for Oral Bioavailability Studies
• Chapter 37 Caco‐2 Cell Culture Model for Oral Drug Absorption
• Chapter 38 OATP Overexpressed Cells and Their Use in Drug Uptake Studies
• Chapter 39 Use of Human Intestinal and Hepatic Tissue Fractions and Microbiome as Models in Assessment of Drug Metabolism and its Impact on Oral Bioavailability
• Chapter 40 Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion
• Chapter 41 Determination of Regulation of Drug Metabolizing Enzymes and Transporters
• Chapter 42 Intestinal Perfusion Methods for Oral Drug Absorptions
• Chapter 43 In Silico Prediction of Oral Drug Absorption
• Chapter 44 Computational Modeling of Drug Oral Bioavailability
• Chapter 45 Blood–Brain Barrier Permeability Assessment for Small‐Molecule Drug Discovery Using Computational Techniques
• Index
• EULA