Oral Bioavailability and Drug Delivery

From Basics to Advanced Concepts and Applications

Ming Hu,Xiaoling Li

• Publisher: Wiley
• Year: 2024
• ISBN:
  9781119660682
• Edition: 1
• Topic: Medicine
• Subtopic: Pharmacology

ORAL BIOAVAILABILITY AND DRUG DELIVERY

Improve the performance and viability of newly-developed and approved drugs with this crucial guide

Bioavailability is the parameter which measures the rate and extent to which a drug reaches a user's circulatory system depending on the method of administration. For example, intravenous administration produces a bioavailability of 100%, since the drugs are injected directly into the circulatory system; in the case of oral administration, however, bioavailability can vary widely based on factors which, if not properly understood, can result in a failure in drug development, adverse effects, and other complications. The mechanics of oral bioavailability are therefore critical aspects of drug development.

Oral Bioavailability and Drug Delivery provides a comprehensive coverage of this subject as well as its drug development applications. Beginning with basic terminology and fundamental concepts, it provides a thorough understanding of the challenges and barriers to oral bioavailability as well as the possibilities for improving this parameter. The resulting book is an indispensable tool for drug development research.

Oral Bioavailability and Drug Delivery readers will also find:

• Discussion questions in many chapters to facilitate comprehension
• Detailed discussion of topics including dissolution, absorption, metabolism, and more
• Real-world examples of methods in actions throughout

Oral Bioavailability and Drug Delivery is ideal for pharmaceutical and biotechnology scientists working in drug discovery and development; researchers in chemistry, biology, pharmacology, immunology, neuroscience, and other related fields; and graduate courses in drug development and delivery.

Table of contents

• Cover
• Table of Contents
• Title Page
• Copyright
• Dedication
• List of Contributors
• Foreword
• Preface
• 1 Barriers to Oral Bioavailability – An Overview
• 2 Solubility of Pharmaceutical Solids
• 3 In Vitro Dissolution of Pharmaceutical Solids
• 4 Biological and Physiological Features of the Gastrointestinal Tract Relevant to Oral Drug Absorption
• 5 Absorption of Drugs Via Passive Diffusion and Carrier-Mediated Pathways
• 6 Determinant Factors for Passive Absorption of Drugs
• 7 Protein Binding and Drug Distribution
• 8 Drug Transport Across the Placental Barrier
• 9 Biopharmaceutics Classification System: Theory and Practice
• 10 Effects of Food on Drug Absorption
• 11 Drug Metabolism in Gastrointestinal Tract
• 12 Liver Drug Metabolism
• 13 Urinary Excretion of Drugs and Drug Reabsorption
• 14 Excretion of Drugs and Their Metabolites into the Bile
• 15 Pharmacokinetic Behaviors of Orally Administered Drugs
• 16 In Vitro-In Vivo Correlations of Pharmaceutical Dosage Forms
• 17 Advanced Concepts in Oral Bioavailability Research – An Overview
• 18 Expression and Pharmaceutical Relevance of Intestinal Transporters
• 19 Amino Acid Transporters
• 20 Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide-Based Pharmaceuticals
• 21 OATP Transporters in Hepatic and Intestinal Uptake of Orally Administered Drugs
• 22 ABC Transporters in Intestinal and Liver Efflux
• 23 Interplay Between Metabolic Enzymes and Transporters
• 24 Systemic Versus Local Bioavailability Enabled by Recycling
• 25 Intestinal Microbiome and Its Impact on Metabolism and Safety of Drugs
• 26 Drug–Drug Interactions and Drug–Dietary Chemical Interactions
• 27 Regulatory Considerations in Metabolism- and Transport-Based Drug Interactions
• 28 Formulation Approaches to Improve Oral Bioavailability of Drugs
• 29 Lipid-Based and Self-Emulsifying Oral Drug Delivery Systems
• 30 Oral Delivery of Nanoparticles: Challenges and Opportunities
• 31 Oral Delivery of Therapeutic Peptides: Strategies for Product Development
• 32 Prodrugs to Improve Oral Delivery
• 33 Gastroretentive Drug Delivery Systems
• 34 Enhancing Oral Bioavailability Using 3D Printing Technology
• 35 Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, Monkeys, and Humans
• 36 In Vivo Methods for Oral Bioavailability Studies
• 37 Caco-2 Cell Culture Model for Oral Drug Absorption
• 38 OATP Overexpressed Cells and Their Use in Drug Uptake Studies
• 39 Use of Human Intestinal and Hepatic Tissue Fractions and Microbiome as Models in Assessment of Drug Metabolism and its Impact on Oral Bioavailability
• 40 Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion
• 41 Determination of Regulation of Drug Metabolizing Enzymes and Transporters
• 42 Intestinal Perfusion Methods for Oral Drug Absorptions
• 43 In Silico Prediction of Oral Drug Absorption
• 44 Computational Modeling of Drug Oral Bioavailability
• 45 Blood–Brain Barrier Permeability Assessment for Small-Molecule Drug Discovery Using Computational Techniques
• Index
• End User License Agreement