Coulometric Electrode Array Detectors for HPLC

I.H. Acworth, M. Naoi, Hasan Parvez, S. Parvez, I.H. Acworth, M. Naoi, Hasan Parvez, S. Parvez

• Publisher: CRC Press
• Year: 2024
• eBook ISBN: 9780429527869
• Topic: Physical Sciences
• Subtopic: Industrial & Technical Chemistry

This sixth volume in the book series Progress in HPLC-HPCE examines the enhancement of high- performance liquid chromatography through the development of an advanced mode of electrochemical detection (ECD) --- the coulometric array detection --- from its initial, yet problematic, amperometric (thin-layer) design to the highly sensitive, selective and stable coulometric (flow-through) design. Unlike amperometric electrodes, the coulometric electrode is 100% efficient and measures signals from all of the analyte passing through it, which leads to improved sensitivity as well as unique selectivity. The coulometric electrode array offers the resolution of the photodiode array with the extreme sensitivity of an electrochemical detector.

Table of contents

• Cover
• Half-Title Page
• Title Page
• Copyright Page
• Table of Contents
• Dedication
• Preface
• An Introduction to HPLC-Based Electrochemical Detection: From Single Electrode to Multi-Electrode Arrays
• Qualitative Utility of Coulometric Array Detection: Theoretical and Applied Aspects
• HPLC with Electrode Array Detection and its Application in Analytical Food Chemistry
• The Measurement of Markers of Oxidative Damage, Anti-Oxidants and Related Compounds Using HPLC and Coulometric Array Analysis
• CEAS Generation of Large Multi-Parameter Metabolic Databases for Determining Categorical Process Involvement of Biological Molecules
• The Application of N-EC-HPLC to the Analysis of Insect Biogenic Amines
• A Phylogenetic Analysis of Biogenic Monoamines in the Central Nervous Systems of Various Organisms and Application to the Fields of Medical Biochemistry
• Multicomponent Quantitations of Monoamines and Related Compounds in Biological Fluids and CNS Tissues by HPLC Coupled with Multi-Electrode Electrochemical Detection
• The Application of the Multi-Electrode Detection System to Neurochemistry: In Vivo Microdialysis Studies
• HPLC-Multi-Electrochemical Detection System: Application to Neurochemical Studies in Pediatrics
• Neurotransmitter Disturbances in Alzheimer’s Disease with Lewy Bodies
• Application of the Multi-Electrode Detection System to the Monitoring of Drug Therapy in Neurological Diseases
• Determination of Illicit Drugs and Related Substances by Using HPLC with an Electrochemical Coulometric Array Detector
• Enantioseparation of Biologically Active Compounds by HPLC
• Analysis of Endogenous Enantiomers of Neurotoxins in Clinical Samples by a Multi-Electrode Detection System with a Chiral Column
• Electrochemical Measurement of Electrochemically Unreactive Compounds: An Examination of the use of Derivatives and Photolysis with HPLC and Coulometric Detection
• Subject index