Molecular Hematology

Drew Provan, Hillard M. Lazarus

• Publisher: Wiley-Blackwell
• Year: 2024
• Print ISBN: 9781394180455
• eBook ISBN: 9781394180479
• Edition: 5
• Topic: Medicine
• Subtopic: Hematology

Provides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated

Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more.

Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, COVID, cancer cell biology, gene therapy and gene editing in clinical practice, as well as the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout.

• Covers the molecular biology of different blood diseases, their pathogeneses, and current molecular research and therapies
• Illustrates the impact of molecular research on hematologic investigations and therapeutics
• Discusses how progress in basic science and therapeutics has improved the diagnosis and care of patients with various hematologic disorders
• Surveys recent developments in cancer-cell biology, with an emphasis on leukemia and lymphoma
• Includes access to a companion Digital Edition providing search across the book, downloadable illustrations, and notation tools

Molecular Hematology is a must-have resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.

Table of contents

• Cover
• Table of Contents
• Title Page
• Copyright Page
• Dedication
• List of contributors
• Foreword
• Preface
• Chapter 1: Beginnings: the molecular pathology of hemoglobin
• Chapter 2: Stem cells
• Chapter 3: The genetics of acute myeloid leukemia
• Chapter 4: Molecular diagnostics and risk assessment in myeloid malignancies
• Chapter 5: Molecular basis of acute lymphoblastic leukemia
• Chapter 6: Chronic myelogenous leukemia
• Chapter 7: Myeloproliferative neoplasms
• Chapter 8: Lymphoma genetics
• Chapter 9: Molecular basis of chronic lymphocytic leukemia
• Chapter 10: The molecular biology of multiple myeloma
• Chapter 11: The molecular basis of bone marrow failure syndromes and red cell enzymopathies
• Chapter 12: Anemia of chronic disease
• Chapter 13: Molecular basis of iron metabolism
• Chapter 14: Perspectives in genomics and sickle cell disease therapeutics
• Chapter 15: Molecular coagulation and thrombophilia
• Chapter 16: The molecular basis of hemophilia
• Chapter 17: The molecular basis of von Willebrand disease
• Chapter 18: Platelet disorders
• Chapter 19: The molecular basis of blood cell alloantigens
• Chapter 20: Functions of blood group antigens
• Chapter 21: Autoimmune hematological disorders
• Chapter 22: Molecular therapeutics in hematology: gene therapy
• Chapter 23: Pharmacogenomics
• Chapter 24: Cancer stem cells
• Chapter 25: CAR‐T cell therapy
• Chapter 26: Molecular basis of transplantation
• Index
• End User License Agreement