Textbook of Von Willebrand Disease

Basic and Clinical Aspects

Augusto B. Federici, Erik E. Berntorp, David Lillicrap, Robert R. Montgomery

• Publisher: Wiley-Blackwell
• Year: 2024
• Print ISBN: 9781119419488
• eBook ISBN: 9781119419471
• Edition: 2
• Topic: Medicine
• Subtopic: Hematology

Comprehensive resource summarizing recent research on von Willebrand disease, showing clinicians how to optimize management of patients with this disorder

The newly revised and updated second edition of Textbook of von Willebrand Disease: Basic and Clinical Aspects, 2 nd edition describes the important and complex role of von Willebrand factor (VWF) in hemostasis and thrombosis, covering not only the current understanding of its molecular biology, but also the association between genetic variants of VWF and different von Willebrand disease (VWD) phenotypes. The text also reviews the important area of the obstetric and gynecological manifestations of VWD, as well as how to manage patients with VWD for surgery.

Many advances in agents are included in this updated edition, as well as the wide topics such as VWF in Angiogenesis, and VWF/ADAMTS13 as risk factors of thrombosis.

Edited by a team of experts in VWD and an international team of contributors, Textbook of von Willebrand Disease covers sample topics such as:

• VWF structure and function, biosynthesis and organization of VWF, modulation of VWF by ADAMTS13 and assessment of VWF clearance
• Clinical, laboratory and molecular markers of different VWD types, from the mild forms of type 1 VWD and the moderate variants types 2A, 2B, 2M, 2N to the most severe type 3 VWD
• Pediatric aspects of VWD and of women with VWD
• Management of GI bleeds and appropriate therapies in surgery, and plasma-derived and recombinant VWF concentrates
• Acquired von Willebrand Syndrome, cardiovascular causes of AVWS, gastrointestinal bleeds in VWD and AVWS, and prophylaxis in von Willebrand disease

Providing complete and accessible coverage of the subject, Textbook of von Willebrand Disease: Basic and Clinical Aspects, 2 nd edition is a valuable resource for hematologists in practice and in training, along with specialists in thrombosis, hemostasis, and bleeding/clotting disorders.

Table of contents

• Cover
• Title Page
• Copyright Page
• Contents
• List of Contributors
• Foreword
• Preface
• Chapter 1 Historical perspective on von Willebrand disease
• Chapter 2 Biosynthesis and organization of von Willebrand factor
• Chapter 3 Von Willebrand factor structure and function
• Chapter 4 Regulation of von Willebrand factor expression
• Chapter 5 Modulation of VWF by ADAMTS13
• Chapter 6 Assessment of VWF clearance
• Chapter 7 Classification of VWD
• Chapter 8 The epidemiology of von Willebrand disease
• Chapter 9 Clinical aspects of von Willebrand disease: bleeding history
• Chapter 10 Laboratory diagnosis of von Willebrand disease: the phenotype
• Chapter 11 Molecular diagnosis of von Willebrand disease: the genotype
• Chapter 12 Clinical, laboratory, and molecular markers of type 1 von Willebrand disease and low von Willebrand factor
• Chapter 13 Clinical and molecular markers of type 1C VWD
• Chapter 14 Clinical and molecular markers of VWD2A
• Chapter 15 Clinical and molecular markers of VWD2B
• Chapter 16 Clinical and molecular markers of type 2M VWD
• Chapter 17 Clinical and molecular markers of VWD2N
• Chapter 18 Clinical, laboratory, and molecular markers of type 3 von Willebrand disease
• Chapter 19 Pediatric aspects of von Willebrand disease
• Chapter 20 Women with von Willebrand Disease
• Chapter 21 The use of desmopressin in von Willebrand disease
• Chapter 22 Plasma-derived and recombinant VWF concentrates
• Chapter 23 Pathophysiology, epidemiology, and management of acquired von Willebrand syndrome
• Chapter 24 Cardiovascular causes of AVWS
• Chapter 25 Von Willebrand factor regulation of angiogenesis and vascular integrity: implications for gastrointestinal angiodysplasia and beyond
• Chapter 26 Prophylaxis in von Willebrand disease
• Chapter 27 Risk of thrombosis and antithrombotic treatment in von Willebrand disease patients
• Chapter 28 Novel functions for VWF beyond hemostasis
• Index
• EULA