SARS-CoV-2 Variants and Global Population Vulnerability

Diagnostic Strategies, Vaccine Development, and Therapeutic Management

Vivek P. Chavda, Vladimir N. Uversky

• Publisher: Apple Academic Press
• Year: 2024
• Print ISBN: 9781774917589
• eBook ISBN: 9781040011942
• Edition: 1
• Topic: Medicine
• Subtopic: Diseases & Allergies

SARS-CoV-2, the coronavirus responsible for COVID-19, wreaked havoc on the world; it could both spread easily and mutate rapidly, leading to the decrease in the effectiveness of newly developed vaccines over time. The detection of these mutated variants and the development of more efficient vaccines requires significant effort and increased knowledge in this field. This new book, SARS-CoV-2 Variants and Global Population Vulnerability: Diagnostic Strategies, Vaccine Development, and Therapeutic Management, provides detailed and systemic information regarding the biology and immunophysiology of SARS-CoV-2 and highlights the global vulnerability of the world population to SARS-CoV-2 infection and COVID-19.

The book covers different aspects pertaining to the SARS-CoV-2 variants and their relation to global vulnerability. Chapters discuss the diagnostics, vaccine development, and therapeutic management starting from the zoonotic origin, organization, and transmission of SARS-CoV-2, lifestyle and immunophysiology of the virus, detection and diagnosis techniques, and analytical techniques. The book also observes the global impact of Delta and Omicron SARS-CoV-2 variants. It looks at the drug repurposing and new drug discovery routines for the emerging variants. It presents strategies for fast-track vaccine development, the roles of nasal vaccines and nucleic acid vaccines for COVID-19 management, monoclonal antibody therapy for the diseases management, along with the use of dietary supplements and nutraceuticals, herbal drugs, and other alternative remedies for COVID-19 management. The book also considers the social and environmental impacts of SARS-CoV-2 variants and the current challenges, outlining aspects that can help in developing more efficacious means for controlling SARS-CoV-2 in the future.

Key highlights:

• Discusses SARS-CoV-2 variants, diagnosis strategies, vaccine development, and the therapeutic management of the disease
• Provides comprehensive coverage of SARS-CoV-2 virus and variants

With its unique and thorough take on the subject, this book is an important resource of know-how for investigators working in this area. Professionals from the pharmaceutical industry as well as students, research scholars, doctors, and other healthcare professionals will find this book of particular value.

Table of contents

• Cover Page
• Half Title Page
• Title Page
• Copyright Page
• Dedication
• About the Editors
• Contents
• Contributors
• Abbreviations
• Foreword
• Preface
• Chapter 1 Zoonotic Origin, Genomic Organization, Transmission, and Mutation of SARS-CoV-2
• Chapter 2 SARS-CoV-2 Life Cycle and Immuno-Pathophysiology
• Chapter 3 Conventional and Novel Diagnostics for the Detection of SARS-CoV-2 Variants
• Chapter 4 Biosensors: An Advanced and Sensitive Analytical Technique for the Early Detection of SARS-CoV-2 Variants
• Chapter 5 Global Impact of Delta and Omicron Variants of SARS-CoV-2
• Chapter 6 Drug Repurposing for COVID-19 and Fast Track New Drug Discovery for Emerging SARS-CoV-2 Variants
• Chapter 7 Characterization of SARS-CoV-2 Variants Using Respiratory Organoids and Organs-on-a-Chip
• Chapter 8 Fast Track Vaccine Development for COVID-19 and Impact of Emerging Variants
• Chapter 9 Nasal Vaccine for the Control of Emerging Variants of SARS-CoV-2
• Chapter 10 Role of Nucleic Acid Vaccines for the Management of Emerging Variants of SARS-CoV-2
• Chapter 11 Role of Monoclonal Antibodies for the Management of Immersing Variant of SARS-CoV-2
• Chapter 12 Dietary Supplements and Nutraceuticals Against the Variants of SARS-CoV-2
• Chapter 13 Herbal Remedies for COVID-19 Management
• Chapter 14 COVID-19 and Post-COVID-19-Associated Complications and Their Management
• Chapter 15 SARS-CoV-2 Variants and Global Vulnerability: Diagnostic, Vaccines, and Therapeutic Management
• Chapter 16 Socio-Economic and Environmental Impact of SARS-CoV-2 Variants
• Chapter 17 Nanotechnology-Based Intervention for COVID-19 Management
• Chapter 18 SARS-CoV-2 Variants and COVID-19 Pandemic: Future Perspectives
• Glossary
• A
• B
• C
• D
• G
• I
• M
• N
• O
• R
• S
• T
• V
• Index