Autoimmune Disorders

Adjuvants and Other Risk Factors in Pathogenesis

Abdulla Watad, Nicola Luigi Bragazzi, Yehuda Shoenfeld

• Publisher: Wiley
• Year: 2024
• Print ISBN: 9781119858416
• eBook ISBN: 9781119858447
• Edition: 1
• Topic: Medicine
• Subtopic: Immunology

Autoimmune Disorders

Comprehensive resource on the science of autoimmune disorders, covering causes, treatment, prevention, and the latest research in the field

Autoimmune Disorders is an authoritative reference on the science of autoimmune disorders, covering their causes, including infections, vaccine adjuvants, environmental stimuli, and silicone implants, the latest research on the genetics, epigenetics, and immunology of autoimmunity, predictive markers, therapeutic approaches for treatment and prevention, and suggestions for future research directions.

This book explores the intricate connections between adjuvants and autoimmune responses, focusing on the emergence of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA syndrome), as well as autoimmune connections in areas such as chronic fatigue syndrome, autoantibodies targeting the autonomic system, and small fiber neuropathy. The authors emphasize the profound impact of vaccines on public health, underscoring that their benefits far outweigh potential side effects and exploring the historical context of adjuvants in vaccine development. From tattoos to environmental factors, each chapter adds a unique thread to the tapestry of adjuvants, autoimmune responses, and their interactions.

Sample topics covered in Autoimmune Disorders include:

• Food additives and dental implants as a trigger of autoimmunity and increased risk of ASIA syndrome as a result of the chemical and social factors
• Sustained immune activation in ASIA syndrome as a bridge to lymphomagenesis and how immune checkpoints, metals, and bisphenol connect to autoimmunity
• Postural Orthostatic Tachycardia syndrome (POTS), Sick Building syndrome, and Gulf War syndrome (GWS) as parts of ASIA syndrome
• Sarcoidosis and Sjögren's syndrome as a proof of concept of hyperstimulation syndrome

Autoimmune Disorders is an essential reference on the subject for academics, specialized postgraduate students, and practicing professionals seeking to improve integrated research strategies and foster a deeper understanding of the complex relationship between immunology, public health, and individual well-being.

Table of contents

• Cover
• Table of Contents
• Title Page
• Copyright
• List of Contributors
• Introduction
• 1 Hyperstimulation of the Immune System
• 2 Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA): Genetics, Immunization, and Autoimmunity
• 3 Vaccine Adjuvants: History, Role, Mechanisms of Action, and Side Effects
• 4 Commonly Used Food Additives Are Nutritional Adjuvants in ASIA Syndrome
• 5 Silicone Implant Incompatibility Syndrome
• 6 Silicone Breast Implants (SBIs) and Autoimmune Dysautonomya
• 7 Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA or Shoenfeld’s Syndrome) Due to Polypropylene Mesh Implants
• 8 Vaccines, Vaccinosis, and Autoimmunity
• 9 Sustained Immune Activation in ASIA Syndrome - A Bridge to Lymphomagenesis
• 10 Chronic Fatigue Syndrome
• 11 Autoantibodies and Autonomic Nervous System
• 12 Postural Orthostatic Tachycardia Syndrome (POTS) as a Part of ASIA Syndrome
• 13 Role of the Small‐fiber Neuropathy in the Pathogenesis of ASIA Syndrome
• 14 Tattoo as a Possible Trigger for Autoimmune Syndrome Induced by Adjuvants
• 15 The Sick Building Syndrome as a Part of the Autoimmune (Autoinflammatory) Syndrome Induced by Adjuvant
• 16 Gulf War Syndrome (GWS) and ASIA Syndrome
• 17 Vaccinations in Patients with Autoimmune Diseases
• 18 Autoimmune Phenomena in Cancer Patients Treated with Immune Checkpoint Inhibitors
• 19 Heavy Metals in Autoimmune Diseases: Too Much Noise in Autoimmunity
• 20 The Role of Bisphenol A in ASIA Syndrome
• 21 Sarcoidosis and Autoimmune Inflammatory Syndrome Induced by Adjuvants: Is There a Connection?
• 22 Sjögren's Syndrome as a Proof of Concept of the Hyperstimulation Syndrome
• 23 Gluteal Biopolymer Injections as a Case of ASIA Syndrome
• 24 The Chemical and Social Landscape of the Modern World and Increased Risk of ASIA
• 25 Oil Injections and ASIA Syndrome
• 26 Metals in Dental Implants as a Trigger of Autoimmunity
• 27 Conclusions: State of the Art and Prospects
• Index
• End User License Agreement