- 214 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
eBook - ePub
Cancer through the Lens of Evolution and Ecology
About this book
Cancer cells exist in an ever-changing "ecology" and are subject to evolutionary pressures just like any species in nature. This edited book explores the following themes: 1) how the dynamics of mutation, epigenetics, and gene expression noise are sources of genetic diversity; 2) how scarce resources influence cancer therapy resistance; 3) how predator-prey dynamics are mirrored in immune-cancer cross-talk; 4) how cancer cells parallel niche construction theory; 5) how changing fitness landscapes enable cancer growth; and 6) how cancer cells interact within the body. The book is a resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms.
Key Features
- Bridges disciplines exemplifying the ways disparate fields create new perspectives when integrated.
- Offers insights from leading scholars in cancer biology, ecology and evolutionary biology.
- Provides a timely recognition by oncologists that evolutionary paradigms are crucial for breakthroughs in cancer treatment.
- Integrates basic and applied sciences of oncology and evolutionary biology.
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Please note we cannot support devices running on iOS 13 and Android 7 or earlier. Learn more about using the app.
Yes, you can access Cancer through the Lens of Evolution and Ecology by Jason A. Somarelli,Norman A. Johnson in PDF and/or ePUB format, as well as other popular books in Medicina & Biología. We have over one million books available in our catalogue for you to explore.
Table of contents
- Cover
- Half Title
- Title
- Copyright
- Contents
- Foreword
- Preface
- Acknowledgments
- About the Editors
- List of Contributors
- Chapter 1 A Species within a Species
- Chapter 2 Therapy as a Driver of Evolutionary Selection
- Chapter 3 The Genetic Hitchhiker’s Guide to Tumor Evolution
- Chapter 4 Multicellularity, Phenotypic Heterogeneity, and Cancer
- Chapter 5 Feedback Loops in Gene Regulatory Networks and Cell-Cell Communication Networks: Drivers of Cancer Cell Plasticity
- Chapter 6 Polygenic Evolution of Germline Variants in Cancer
- Chapter 7 Two-Phased Cancer Evolution: The Pattern and Scale of Genomic and Non-Genomic Landscapes
- Chapter 8 Evolutionary and Ecological Perspective on the Multiple States of T Cell Exhaustion
- Chapter 9 Landscape Genetics for Cancer Biology
- Chapter 10 Tumor Island Biogeography: Theory and Clinical Applications
- Chapter 11 Cancer and the Evolutionary Ecology of Invasions
- Chapter 12 Unifying Theories in Comparative Oncology
- Chapter 13 From Evolutionary Biology to Bedside and Beyond: A View of Comparative Oncology throughout the Translational Pipeline
- Chapter 14 What Do We Gain from Viewing Cancer through an Eco-Evo Lens?
- Index