Developmental Toxicology
eBook - ePub

Developmental Toxicology

  1. 496 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Developmental Toxicology

About this book

Highlighting latest advances in genetics and biochemistry, the completely revised Third Edition reviews the field from basic science, clinical, epidemiological, and regulatory perspectives. Contributions from top opinion leaders in the field bring together developments in molecular embryology and cell biology as they apply to problems in developmental toxicology. It covers testing of pharmaceutical and environmental agents and interpretation of developmental toxicology data, highlighting mathematical and statistical techniques, as well as the effects of toxic exposure on the functional development of various organs.

The relationship between maternal and developmental toxicology is examined, in addition to current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the regulatory aspects of testing and risk assessment. Pre- and postconceptional clinical care and genetic factors in clinical developmental toxicology are also discussed.

Key topics include:







  • the roles of apoptosis and signal transduction pathways in normal and abnormal development


  • the role of epigenetic changes in development


  • the role of nutrition and individual susceptibility


  • the utility of bioinformatics


  • global and targeted gene expression changes.

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Information

Publisher
CRC Press
Year
2008
Print ISBN
9781138372443
eBook ISBN
9781040173046
Topic
Medicine
Subtopic
Gynecology, Obstetrics & Midwifery

Table of contents

  1. Cover
  2. Half Title
  3. Series Page
  4. Title Page
  5. Copyright Page
  6. Preface
  7. Acknowledgments
  8. Table of Contents
  9. Contributors
  10. 1. Role of Apoptosis in Normal and Abnormal Development
  11. 2. Signal Transduction Pathways as Targets for Teratogens
  12. 3. Nutrition in Developmental Toxicology
  13. 4. Epigenetic Mechanisms: Role of DNA Methylation, Histone Modifications, and Imprinting
  14. 5. Personalized Nutrition and Medicine in Perinatal Development
  15. 6. Targeted Gene Changes Affecting Developmental Toxicity
  16. 7. Use of Mammalian In Vitro Systems, Including Embryonic Stem Cells, in Developmental Toxicity Testing
  17. 8. Zebrafish: A Nonmammalian Model of Developmental Toxicology
  18. 9. Physiologically Based Pharmacokinetic Modeling in the Risk Assessment of Developmental Toxicants
  19. 10. Integration of Whole Animal Developmental Toxicity Data into Risk Assessment
  20. 11. Genomic Approaches in Developmental Toxicology
  21. 12. Comparative Bioinformatics and Computational Toxicology
  22. 13. Investigating Drug Effects in Human Pregnancy
  23. Index

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Yes, you can access Developmental Toxicology by Deborah K. Hansen,Barbara D. Abbott in PDF and/or ePUB format, as well as other popular books in Medicine & Gynecology, Obstetrics & Midwifery. We have over one million books available in our catalogue for you to explore.