Stimuli-Responsive Hydrogels for Ophthalmic Drug Delivery

Dipankar Chattopadhyay, Jonathan Tersur Orasugh, Anjan Adhikari, Suprakas Sinha Ray

• Publisher: Woodhead Publishing
• Year: 2024
• Print ISBN:
  9780323991568
• eBook ISBN:
  9780323993593
• Topic: Technology & Engineering
• Subtopic: Biotechnology in Medicine
• Index: Technology & Engineering

This book covers fundamental aspects in the preparation of polymeric in-situ, stimuli-responsive hydrogels; the properties, characterization, chemistry, and fabrication of these hydrogels is detailed, helping the reader to select the most appropriate material and design for the desired application. The book goes on to review applications in ophthalmic drug delivery, covering in vitro and in vivo models, animal models, preclinical testing, patents and more. Stimuli-responsive Hydrogels for Ophthalmic Drug Delivery is a must-have reference for researchers and academics in the fields of materials science, biomaterials, pharmacology and polymer science, with an interest in clinical aspects of hydrogel design and application. - Provides step-by-step coverage for engineering in-situ and stimuli-responsive hydrogels, from design, characterization, and toxicity considerations to fabrication, process optimization, and drug release kinetics - Utilizes an interdisciplinary approach, bringing together authors from pharmacology, polymer science, and medical backgrounds - Details the advantages and challenges of using stimuli-responsive hydrogels for ophthalmic drug delivery, with a focus on clinical translation

Table of contents

• Cover
• Front Matter
• Table of Contents
• Copyright
• Dedication
• Preface
• List of Illustrations
• List of Tables
• Chapter 1 : Introduction
• Chapter 2 : Introduction to polymeric in situ forming hydrogels for ophthalmic drug delivery
• Chapter 3 : Biopolymers for in situ–forming hydrogels, synthesis, characterization, toxicity issues, and application
• Chapter 4 : Biopolymer stimuli-responsive in situ hydrogels, chemistry, and their potential applications in ODDS
• Chapter 5 : Fabrication of biopolymer in situ–forming hydrogels
• Chapter 6 : Modeling: Process optimization for design, engineering, and fabrication of biopolymer in situ–forming hydrogels
• Chapter 7 : Properties of biopolymeric in situ hydrogel-based biomaterials
• Chapter 8 : Swelling and drug release kinetics of biopolymer in situ–forming hydrogels for ophthalmic drug delivery
• Chapter 9 : Structural load-bearing characteristics of biopolymer in situ–forming hydrogels for ophthalmic drug delivery
• Chapter 10 : Functionalization and its effect on the properties of in situ–forming biopolymer hydrogels
• Chapter 11 : Application of biopolymer in situ–forming hydrogels in ophthalmic drug delivery system and others
• Chapter 12 : Eye anatomy, physiology, and ocular barriers
• Chapter 13 : Models/techniques to evaluate ophthalmic drug delivery formulations
• Chapter 14 : Formulation/design concepts based on the features/barriers of ocular drug deliveries
• Chapter 15 : Clinical indications that need a thermoresponsive hydrogel
• Chapter 16 : An overview on materials/polymers suitable for stimuli-responsive hydrogels: Natural or synthetic
• Chapter 17 : Viscoelastic characteristics and gelation kinetics of in situ–forming hydrogels
• Chapter 18 : Degradation kinetics of in situ–forming hydrogels
• Chapter 19 : Cell-laden stimuli-responsive hydrogels, their fabrication, and application
• Chapter 20 : Animal models and preclinical tests to evaluate in situ–forming hydrogels
• Chapter 21 : Biopolymer-based in situ–forming hydrogels: From laboratory to practical application
• Chapter 22 : Commercially available in situ gelling hydrogels for biomedical applications
• Chapter 23 : Challenges, suggestive way out, and future of perspective of biopolymer in situ hydrogels in biomedical applications
• Chapter 24 : Patents for biopolymer in situ–forming hydrogels for ophthalmic drug delivery and tissue regeneration
• References
• Index
• A