Regulatory T cells and Autoimmune Diseases

Mitesh Kumar Dwivedi, DeLisa Fairweather, Mitesh Kumar Dwivedi, DeLisa Fairweather

• Publisher: Academic Press
• Year: 2024
• Print ISBN:
  9780443139475
• eBook ISBN:
  9780443139482
• Topic: Médecine
• Subtopic: Immunologie

Regulatory T cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic aspects. In particular, this book deals with the various Treg based mechanisms which can lead to autoimmune diseases and covers the different aspects of linking Tregs with autoimmune mechanisms involved in disease development by discussing animal models and human studies. The book specifically focuses on the Treg based therapeutics and their targets to manage all known autoimmune rheumatic, central nervous system, bowel, liver, thyroid, kidney, myopathic, skin, blood & blood vessel, and eye diseases and aims to provide a must-have reference for designing therapeutic strategies to treat these autoimmune diseases. Additionally, the book covers the vaccines induced effects on functioning of Tregs and development of CAR Tregs therapy for these autoimmune diseases and concludes with current challenges and future prospects of Treg-based therapeutics. It is carefully designed to meet the requirements of both basic and advanced researchers in the area and give new dimensions and insight into the regulatory T cells' role in autoimmune disease pathogenesis and therapeutic aspects. - Brings the reader up-to-date on the mechanisms of regulatory T cells (Tregs) in pathogenesis and therapeutics of all autoimmune diseases known to date - Provides explicit color illustrations and comprehensible tables for explaining the mechanistic aspects and emerging information in the field - Includes human clinical trials and animal model studies for Tregs in diverse autoimmune diseases for the mitigation of the symptoms of autoimmune diseases - Offers scientifically applicable and relevant content for readers of various disciplines, including biomedical sciences, medical microbiology/biotechnology, immunology, and medicine

Table of contents

• Regulatory T Cells and Autoimmune Diseases
• Chapter 1 Regulatory T cells and their functions in immune system
• Chapter 2 Regulatory T cells: mechanisms of action
• Chapter 3 Regulatory T cells and autoimmunity
• Chapter 4 Sex differences in regulatory T cells during autoimmune disease
• Chapter 5 Role of regulatory T cells in pathogenesis and therapeutics of systemic lupus erythematosus
• Chapter 6 Role of regulatory T cells in the pathogenesis and therapeutics of primary Sjögren’s syndrome
• Chapter 7 Role of regulatory T cells in pathogenesis and therapeutics of rheumatoid arthritis and juvenile idiopathic arthritis
• Chapter 8 Role of regulatory T cells in pathogenesis and therapeutics of psoriatic arthritis
• Chapter 9 Role of regulatory T cells in pathogenesis and therapeutics of spondyloarthritis
• Chapter 10 Role of regulatory T cells in pathogenesis and therapeutics of ankylosing spondylitis
• Chapter 11 Role of regulatory T cells in pathogenesis and therapeutics of multiple sclerosis
• Chapter 12 Role of regulatory T cells in the pathogenesis and therapeutics of neuromyelitis optica spectrum disorder
• Chapter 13 Role of regulatory T cells in pathogenesis and therapeutics of myasthenia gravis
• Chapter 14 Role of regulatory T cells in pathogenesis and therapeutics of Guillain–Barré syndrome and experimental autoimmune neuritis
• Chapter 15 Role of regulatory T cells in pathogenesis and therapeutics of chronic inflammatory demyelinating polyradiculoneuropathy
• Chapter 16 Role of regulatory T cells in pathogenesis and therapeutics of dermatomyositis and polymyositis
• Chapter 17 Role of regulatory T cells in pathogenesis and therapeutics of Crohn’s disease and ulcerative colitis
• Chapter 18 Role of regulatory T cells in pathogenesis and therapeutics of celiac disease
• Chapter 19 Role of regulatory T cells in the pathogenesis and therapeutics of autoimmune hepatitis
• Chapter 20 Role of regulatory T cells in pathogenesis and therapeutics of primary biliary cholangitis and primary sclerosing cholangitis
• Chapter 21 Role of regulatory T cells in pathogenesis and therapeutics of Hashimoto’s thyroiditis
• Chapter 22 Role of regulatory T cells in pathogenesis and therapeutics of Graves’ disease and Graves’ orbitopathy
• Chapter 23 Role of regulatory T cells in pathogenesis and therapeutics of Goodpasture’s syndrome (anti-glomerular basement membrane disease)
• Chapter 24 Role of regulatory T cells in pathogenesis and therapeutics of autoimmune glomerulonephritis (IgA vasculitis and IgA nephropathy)
• Chapter 25 Role of regulatory T cells in pathogenesis and therapeutics of vitiligo
• Chapter 26 Role of regulatory T cells in pathogenesis and therapeutics of psoriasis
• Chapter 27 Role of regulatory T cells in pathogenesis and therapeutics of atopic dermatitis
• Chapter 28 Role of regulatory T cells in pathogenesis and therapeutics of alopecia areata
• Chapter 29 Role of regulatory T cells in pathogenesis and therapeutics of pemphigus vulgaris and bullous pemphigoid
• Chapter 30 Role of regulatory T cells in pathogenesis and therapeutics of scleroderma (systemic sclerosis)
• Chapter 31 Role of regulatory T cells in pathogenesis and therapeutics of primary antiphospholipid syndrome (Hughes syndrome)
• Chapter 32 Role of regulatory T cells in the pathogenesis and therapeutics of Kawasaki disease
• Chapter 33 Role of regulatory T cells in pathogenesis and therapeutics of Behçet disease
• Chapter 34 Role of regulatory T cells in pathogenesis and therapeutics of immune thrombocytopenia
• Chapter 35 Role of regulatory T cells in pathogenesis and treatment of antineutrophil cytoplasmic antibody-associated vasculitis
• Chapter 36 Role of regulatory T cells in pathogenesis and therapeutics of autoimmune hemolytic anemia
• Chapter 37 Role of regulatory T cells in pathogenesis and therapeutics of autoimmune uveitis
• Chapter 38 Role of regulatory T cells in pathogenesis and therapeutics of autoimmune retinopathy
• Chapter 39 Role of regulatory T cells in the pathogenesis and therapeutics of type 1 diabetes mellitus
• Chapter 40 Vaccine-induced effects on regulatory T cell function: autoimmune perspective
• Chapter 41 Probiotic interventions for regulatory T cells’ induction in autoimmune diseases
• Chapter 42 CAR Treg-based therapeutics for autoimmune diseases
• Chapter 43 Current challenges and future prospects of regulatory T-cell based therapeutics in autoimmune diseases
• Index