Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics

Ting-Chao Chou

• Publisher: Academic Press
• Year: 2024
• Print ISBN:
  9780443288746
• eBook ISBN:
  9780443288753
• Topic: Sciences biologiques
• Subtopic: Biologie

"Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics provides a comprehensive overview and update of the mass-action law-based unified dose-effect biodynamics, pharmacodynamics, bioinformatics, and the combination index theorem for synergy definition (MAL-BD/PD/BI/CI). Contents advocate the fundamental MAL-PD/BI/CI/BI principle for biomedical R&D, clinical trials protocol design computerized data analysis, illustrates the MAL-dynamics theory with sample analysis, and includes data entry and automated computer report print-outs. In 11 sections "Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics leads the reader from an introduction and overview, to trial protocols and MAL-PD/CI approach for biomedical R&D in vitro and in animals. It describes the current Landscape of International FDA Drug Evaluation, Clinical Pharmacology, and Clinical Trials Guidance. This is a valuable resource for biomedical researchers, healthcare professionals, and students seeking to harness the power of data informatics in precision medicine.• gives insight into that index equation (DRIE) that digitally determines how many folds of dose-reduction is needed for each drug in synergistic combinations • provides a comprehensive overview and update of mass-action law-based unified bioinformatics, dose effect biodynamics, pharmacodynamics, and the combination index theorem for synergy definition (MAL-BD/PD/BI/CI) • describes how the MAL theory/algorithm-based "Top-Down digital approach is the opposite and yet is a complementary alternative to the observation/statistics-based "Bottom-Up traditional approach in R&D

Table of contents

• Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics
• Chapter I A new alternative concept for cost-effective R&D: The MAL-dynamics/algorithms/digital informatics⊛
• Chapter II General dynamics principle for experimental design of all dose-effect analysis and computer simulation⊛
• Chapter III MAL-PD/CI approach for biomedical R&D in vitro and in animals⊛
• Chapter IV Implementation of MAL-PD for Econo-Green R&D⊛
• Chapter V Digital R&D approach to international FDA drug evaluation, clinical pharmacology, and clinical trial guidance⊛
• Chapter VI The epothilone story: Experimental success and clinical failure⊛
• Chapter VII MAL-PD advocacy: Public hearing, public comments and scientific recommendations⊛
• Chapter VIII Consensus for international FDAs on definitions of “MAL-PD” and “Synergism”⊛
• Chapter IX Historical, philosophical, and mathematical analysis: Why the MAL-PD approach and the traditional approach are opposite yet complementary⊛
• Chapter X Multidisciplinary examples of applications: Papers using the MAL-PD/BD/CI/BI theory/method⊛
• Chapter XI Concluding remarks⊛
• Postscript
• Summary
• Appendix I
• Appendix II
• Appendix III
• Appendix IV
• Appendix V
• Appendix VI
• Glossary and definitions
• Research supports
• Index