Principles of Translational Science in Medicine
eBook - ePub

Principles of Translational Science in Medicine

From Bench to Bedside

  1. 494 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Principles of Translational Science in Medicine

From Bench to Bedside

About this book

Principles of Translational Science in Medicine: From Bench to Bedside, Third Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing number of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. New chapters include: Translation in Oncology, Biologicals, and Orphan Drugs. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine and is written by worldwide experts in their respective fields. - Includes state-of-the-art principles, tools such as biomarkers and early clinical trials, algorithms of translational science in medicine - Provides in-depth description of special translational aspects in the currently most successful areas of clinical translation, namely oncology and immunology - Covers status of institutionalization of translational medicine, networking structures and outcomes at the level of marketing authorization

Trusted by 375,005 students

Access to over 1.5 million titles for a fair monthly price.

Study more efficiently using our study tools.

Information

Publisher
Academic Press
Year
2021
Edition
3
eBook ISBN
9780323999625
Topic
Biological Sciences
Subtopic
Medical Theory, Practice & Reference
Index
Biological Sciences

Table of contents

  1. Cover
  2. Title page
  3. Table of Contents
  4. Copyright
  5. Contents
  6. List of contributors
  7. List of Illustrations
  8. List of Tables
  9. Chapter 1 : Introduction and definitions
  10. Chapter 2 : Problems, challenges, and initiatives in translation
  11. Chapter 3 : “Omics” translation: a challenge for laboratory medicine
  12. Chapter 4 : The power of genomics, metabolomics, and other omics for target identification and validation
  13. Chapter 5 : Potency analysis of cellular therapies: the role of molecular assays
  14. Chapter 6 : Translational pharmacogenetics: pharmacogenetically driven clinical decision making
  15. Chapter 7 : Tissue biobanks
  16. Chapter 8 : Animal models: value and translational potency
  17. Chapter 9 : Biomarkers in the context of health authorities and consortia
  18. Chapter 10 : Human studies as a source of target information
  19. Chapter 11 : Target profiling in terms of translatability and early translation planning
  20. Chapter 12 : Biomarkers
  21. Chapter 13 : Genetics, molecular biomarkers, and artificial intelligence to improve diagnostic and prognostic efficacy
  22. Chapter 14 : Cardiovascular translational biomarkers: translational aspects of hypertension, atherosclerosis, and heart failure in drug development in the digital era
  23. Chapter 15 : Biomarkers in oncology
  24. Chapter 16 : Translational medicine in psychiatry: challenges and imaging biomarkers
  25. Chapter 17 : Methodological studies
  26. Chapter 18 : The pharmaceutical research and development productivity crisis: can exploratory clinical studies be of any help?
  27. Chapter 19 : Adaptive trial design
  28. Chapter 20 : Combining regulatory and exploratory trials
  29. Chapter 21 : Accelerating proof of concept by smart early clinical trials
  30. Chapter 22 : Pharmaceutical toxicology
  31. Chapter 23 : Translational safety medicine
  32. Chapter 24 : Cancer vaccines: translational strategies
  33. Chapter 25 : Translational aspects of biologicals: monoclonal antibodies and antibody-drug conjugates as examples
  34. Chapter 26 : Orphan drugs: why is translation so successful?
  35. Chapter 27 : Translational science biostatistics
  36. Chapter 28 : Computational biology and model-based approaches in translational medicine
  37. Chapter 29 : Intellectual property and innovation in translational medicine
  38. Chapter 30 : Translational research in the fastest-growing population: older adults
  39. Chapter 31 : Translational medicine: the changing role of big pharma
  40. Chapter 32 : Translational science in medicine: putting the pieces together-biomarkers, early human trials, networking, and translatability assessment
  41. Chapter 33 : Learning by experience
  42. Index
  43. A

Frequently asked questions

Yes, you can cancel anytime from the Subscription tab in your account settings on the Perlego website. Your subscription will stay active until the end of your current billing period. Learn how to cancel your subscription
No, books cannot be downloaded as external files, such as PDFs, for use outside of Perlego. However, you can download books within the Perlego app for offline reading on mobile or tablet. Learn how to download books offline
Perlego offers two plans: Essential and Complete
  • Essential is ideal for learners and professionals who enjoy exploring a wide range of subjects. Access the Essential Library with 800,000+ trusted titles and best-sellers across business, personal growth, and the humanities. Includes unlimited reading time and Standard Read Aloud voice.
  • Complete: Perfect for advanced learners and researchers needing full, unrestricted access. Unlock 1.5M+ books across hundreds of subjects, including academic and specialized titles. The Complete Plan also includes advanced features like Premium Read Aloud and Research Assistant.
Both plans are available with monthly, semester, or annual billing cycles.
We are an online textbook subscription service, where you can get access to an entire online library for less than the price of a single book per month. With over 1.5 million books across 990+ topics, we’ve got you covered! Learn about our mission
Look out for the read-aloud symbol on your next book to see if you can listen to it. The read-aloud tool reads text aloud for you, highlighting the text as it is being read. You can pause it, speed it up and slow it down. Learn more about Read Aloud
Yes! You can use the Perlego app on both iOS and Android devices to read anytime, anywhere — even offline. Perfect for commutes or when you’re on the go.
Please note we cannot support devices running on iOS 13 and Android 7 or earlier. Learn more about using the app
Yes, you can access Principles of Translational Science in Medicine by Martin Wehling in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Medical Theory, Practice & Reference. We have over 1.5 million books available in our catalogue for you to explore.