Molecular Biology of B Cells

Tasuku Honjo, Michael Reth, Andreas Radbruch, Frederick Alt, Alberto Martin, Tasuku Honjo, Michael Reth, Andreas Radbruch, Frederick Alt, Alberto Martin

• Publisher: Academic Press
• Year: 2024
• Edition: 3
• eBook ISBN:
  9780323958967
• Topic: Biological Sciences
• Subtopic: Immunology
• Index: Biological Sciences

Molecular Biology of B Cells, Third Edition is a comprehensive reference to how B cells are generated, selected, activated, and engaged in antibody production. These developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Third Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on B cell development and function, the use of therapeutic antibodies in cancer and infectious disease, therapeutic targeting of B cells for clinical application, new developments in lymphoma biology. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Third Edition is the definitive resource, vital for researchers across molecular biology, immunology, and genetics. - Provides new research on normal versus abnormal B cell development and function - Contains studies on therapeutic antibodies in cancer and infectious diseases - Covers research on therapeutically targeting B cells in inflammation or autoimmune diseases

Table of contents

• Molecular Biology of B Cells
• Cover
• Title Page
• Copyright
• Contents
• Contributors
• Preface
• Chapter 1 The Structure and Regulation of the Immunoglobulin Loci
• Chapter 2 The Mechanism, Regulation and Evolution of V(D)J Recombination
• Chapter 3 The Origin of V(D)J Diversification
• Chapter 4 The Variable Lymphocyte Receptor B System of the Jawless Vertebrates
• Chapter 5 Structure and Signalling Function of the B-Cell Antigen Receptor and Its Coreceptors
• Chapter 6 Fc Receptors
• Chapter 7 Transcriptional Regulation of Early B-Cell Development
• Chapter 8 Relationship between B-Cell Populations, Development and Function of B-Cell Subsets
• Chapter 9 B-Cell Development to Immunity and Tolerance
• Chapter 10 The Role of the BAFF and Lymphotoxin Pathways in B Cell Biology
• Chapter 11 Mechanism and Regulation of Immunoglobulin Class Switch Recombination
• Chapter 12 Somatic Hypermutation
• Chapter 13 Molecular Mechanism of Activation-Induced Cytidine Deaminase
• Chapter 14 Molecular Pathogenesis of B-Cell Lymphomas
• Chapter 15 Human Immunodeficiencies Caused by Inborn Errors of B-Cell Development or Function
• Chapter 16 Memory B Cells and Plasma Cells
• Chapter 17 Homoeostatic Versus Pathogenic Autoantibodies: Origin, Structure and Effector Functions
• Chapter 18 Anti-Tumour Necrosis Factor and New Paradigms for Therapies Using Antibodies
• Chapter 19 Therapeutic Targeting of B Cells and Plasma Cells with a Focus on Multiple Sclerosis and Other Autoimmune Conditions
• Chapter 20 IMGT Immunoglobulin Repertoire Analysis and Antibody Humanization
• Chapter 21 Mucosal Immunity to Bacteria and Immunoglobulin A Synthesis
• Chapter 22 B-Cell Metabolism
• Index